ArticlePloS one2016
Clinical and Epidemiologic Characteristics of Hospitalized Patients with Laboratory-Confirmed Respiratory Syncytial Virus Infection in Eastern China between 2009 and 2013: A Retrospective Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- What 'case definition' for respiratory syncytial virus infection? Results of a systematic literature review to improve surveillance among the adults.Journal of public health (Oxford, England) · 2024Pooled it
- Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections.Clinical microbiology reviews · 2019Guideline
- Epidemiology and clinical impact of pediatric RSV co-infections after the COVID-19 pandemic: a narrative review.Frontiers in pediatrics · 2026Review
- Risk factors for recurrent wheezing after infant bronchiolitis: a 6-year single-centre follow up study in China.Frontiers in pediatrics · 2025Article
- Vitamin D Status in Roma Mothers and Newborns: Socioeconomic Factors and Impact on Neonatal Outcome.Nutrients · 2024Article
- The changing pattern of common respiratory viruses among children from 2018 to 2021 in Wuhan, China.Archives of virology · 2023Article
- The Impact of Vitamin D Deficiency on Infants' Health.Nutrients · 2023Review
- Admissions for Bronchiolitis at Children's Hospitals Before and During the COVID-19 Pandemic.JAMA network open · 2023Article
- Age and respiratory syncytial virus etiology in bronchiolitis clinical outcomes.The journal of allergy and clinical immunology. Global · 2022Article
- Hospitalization rate of respiratory syncytial virus-associated acute lower respiratory infection among young children in Suzhou, China, 2010-2014.Influenza and other respiratory viruses · 2022Article
- Respiratory Syncytial Virus: New Challenges for Molecular Epidemiology Surveillance and Vaccination Strategy in Patients with ILI/SARI.Vaccines · 2021Article
- Risk factors for recurrent wheezing after bronchiolitis in infants: 2-year follow up in China.BMC infectious diseases · 2021Article
- Clinical outcomes of adults hospitalized for laboratory confirmed respiratory syncytial virus or influenza virus infection.PloS one · 2021Article
- Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During aFrontiers in pediatrics · 2021Article
- Severity and mortality of respiratory syncytial virus vs influenza A infection in hospitalized adults in China.Influenza and other respiratory viruses · 2020Article
- Molecular epidemiology of influenza, RSV, and other respiratory infections among children in Qatar: A six years report (2012-2017).International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Analysis of genetic variability of respiratory syncytial virus groups A and B in Kuwait.Archives of virology · 2018Article
- The burden of seasonal respiratory infections on a national telehealth service in England.Epidemiology and infection · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory syncytial virus (RSV) is a leading cause of morbidity and mortality worldwide in children aged <5 years and older adults with acute lower respiratory infections (ALRIs). However, few studies regarding the epidemiology of hospitalizations for RSV infection have been performed previously in China. Here, we aimed to describe the clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed RSV infection in eastern China. Active surveillance for hospitalized ALRI patients using a broad case definition based on symptoms was performed from 2009-2013 in 12 sentinel hospitals in eastern China. Clinical and epidemiologic data pertaining to hospitalized patients of all ages with laboratory-confirmed RSV infection by PCR assay were collected and analyzed in this study. From 2009 to 2013, 1046 hospitalized patients with laboratory-confirmed RSV infection were enrolled in this study, and 14.7% of patients had subtype A, 24.2% of patients had subtype B, 23.8% of patients with subtype not performed, and 37.3% of patients had RSV coinfections with other viruses. RSV and influenza coinfections (33.3%) were the most common coinfections noted in this study. Moreover, young children aged <5 years (89.1%, 932/1046), particularly young infants aged <1 year (43.3%, 453/1046), represented the highest proportion of patients with RSV infections. In contrast, older adults aged ≥60 years (1.1%, 12/1046) represented the lowest proportion of patients with RSV infections among enrolled patients. The peak RSV infection period occurred mainly during autumn and winter, and 57% and 66% of patients exhibited symptoms such as fever (body temperature ≥38°C) and cough separately. Additionally, only a small number of patients were treated with broad-spectrum antiviral drugs, and most of patients were treated with antimicrobial drugs that were not appropriate for RSV infection. RSV is a leading viral pathogen and a common cause of viral infection in young children aged <5 years with ALRIs in eastern China. Effective vaccines and antiviral agents targeting RSV are needed to mitigate its large public health impact.
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