Evidence map›Paper›PMID 27802268›Full record

ArticlePloS one2016

Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging.

Mark A Lum, Alastair J Martin, Matthew D Alexander, David B McCoy, Daniel L Cooke, Prasheel Lillaney, Parham Moftakhar, Matthew R Amans, Fabio Settecase, Andrew Nicholson and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Evaluating the effectiveness of preoperative embolization for meningioma with pial feeders: Analysis of perfusion magnetic resonance imaging.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mark A LumSchool of Medicine, University of California San Francisco, San Francisco, California, United States of America.ORCID http://orcid.org/0000-0002-6634-6413
Alastair J MartinDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Matthew D AlexanderDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
David B McCoyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Daniel L CookeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Prasheel LillaneyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Parham MoftakharDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Matthew R AmansDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Fabio SettecaseDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Andrew NicholsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Christopher F DowdDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Van V HalbachDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Randall T HigashidaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Michael W McDermottDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America.
David SalonerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
Steven W HettsDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Endovascular Magnetic Catheter for Interventional MRIR01EB012031 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM, MARTIN, ALASTAIR J · 2011 to 2021
$4.8M
Endovascular Chemofiltration: Optimizing Removal of Chemotherapeutics and Nanoparticles from the Blood to Reduce ToxicityR01CA194533 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM · 2015 to 2019
$2.6M
Image-Guided Monitoring of Meningioma Embolization in a Combined MRI/XRA SuiteR21CA123840 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALONER, DAVID A · 2007 to 2008
$586k
NCATS NIH HHS UL1 TR000004NCI NIH HHS R01 CA194533NCI NIH HHS R21 CA123840NIBIB NIH HHS R01 EB012031
6 · The paper itself

Abstract

background and purposeTo evaluate the ability of IA MR perfusion to characterize meningioma blood supply.

methodsStudies were performed in a suite comprised of an x-ray angiography unit and 1.5T MR scanner that permitted intraprocedural patient movement between the imaging modalities. Patients underwent intra-arterial (IA) and intravenous (IV) T2* dynamic susceptibility MR perfusion immediately prior to meningioma embolization. Regional tumor arterial supply was characterized by digital subtraction angiography and classified as external carotid artery (ECA) dural, internal carotid artery (ICA) dural, or pial. MR perfusion data regions of interest (ROIs) were analyzed in regions with different vascular supply to extract peak height, full-width at half-maximum (FWHM), relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and mean transit time (MTT). Linear mixed modeling was used to identify perfusion curve parameter differences for each ROI for IA and IV MR imaging techniques. IA vs. IV perfusion parameters were also directly compared for each ROI using linear mixed modeling.

results18 ROIs were analyzed in 12 patients. Arterial supply was identified as ECA dural (n = 11), ICA dural (n = 4), or pial (n = 3). FWHM, rCBV, and rCBF showed statistically significant differences between ROIs for IA MR perfusion. Peak Height and FWHM showed statistically significant differences between ROIs for IV MR perfusion. RCBV and MTT were significantly lower for IA perfusion in the Dural ECA compared to IV perfusion. Relative CBF in IA MR was found to be significantly higher in the Dural ICA region and MTT significantly lower compared to IV perfusion.

Indexed as

Angiography, Digital SubtractionBlood VolumeBrainCarotid Artery, ExternalCarotid Artery, InternalCerebrovascular CirculationContrast MediaHumansImage EnhancementMagnetic Resonance AngiographyMeningeal NeoplasmsMeningiomaPerfusion ImagingContrast Media

Identifiers

PMID27802268
PMCPMC5089755

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.