ArticleCancer biomarkers : section A of Disease markers2017
Serum microRNA-15a level acts as a potential diagnostic and prognostic biomarker for human esophageal squamous cell carcinoma.
Article in Cancer biomarkers : section A of Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics.BioMed research international · 2019Pooled it
- Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.Clinical and translational gastroenterology · 2018Pooled it
- Article
- Expression patterns, regulatory interactions, and diagnostic potential of LINC00839 and LINC01605 in esophageal cancer.Biochemistry and biophysics reports · 2025Article
- Prediction of miRNA-disease associations based on PCA and cascade forest.BMC bioinformatics · 2024Article
- Construction of aRenal failure · 2024Article
- Plasma microRNA-15a/16-1-based machine learning for early detection of hepatitis B virus-related hepatocellular carcinoma.Liver research (Beijing, China) · 2024Article
- Article
- The Diagnostic and Prognostic Value of a Liquid Biopsy for Esophageal Cancer: A Systematic Review and Meta-Analysis.Cancers · 2020Review
- MicroRNA-15a tissue expression is a prognostic marker for survival in patients with clear cell renal cell carcinoma.Clinical and experimental medicine · 2019Article
- The expression levels of miRNA-15a and miRNA-16-1 in circulating tumor cells of patients with diffuse large B-cell lymphoma.Molecular biology reports · 2019Article
- Diagnostic and prognostic value of serum miRNA-1290 in human esophageal squamous cell carcinoma.Cancer biomarkers : section A of Disease markers · 2019Article
- Down-regulated serum miR-126 is associated with aggressive progression and poor prognosis of gastric cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Diagnostic and Prognostic Value of Circulating MicroRNAs for Esophageal Squamous Cell Carcinoma: a Systematic Review and Meta-analysis.Journal of Cancer · 2018Article
- MicroRNA-381 enhances radiosensitivity in esophageal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein.OncoTargets and therapy · 2017Article
- miR-25 is upregulated before the occurrence of esophageal squamous cell carcinoma.American journal of translational research · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical significance of microRNA (miR)-15a in human esophageal squamous cell carcinoma (ESCC) remains unclear.
objectiveTo evaluate the expression level of miR-15a and to determine its potential for diagnosis and prognosis in ESCC.
methodsQuantitative reverse transcription polymerase chain reaction was performed to examine the expression levels of miR-15a in ESCC tissues and patients' sera. The diagnostic and prognostic implications of serum miR-15a level in human ESCC were further evaluated.
resultsExpression levels of miR-15a in ESCC tissues and patients' sera were significantly decreased (both P< 0.001). Additionally, serum miR-15a had an optimal diagnostic cut-off point (2.29) for ESCC with sensitivity of 86.36% and specificity of 100.00%. Moreover, low serum miR-15a level more frequently occurred in ESCC patients with advanced tumor-node-metastasis, T and N stages (all P= 0.01) and poor tumor differentiation (P= 0.03). The Kaplan-Meier curve showed that low miR-15a expression was significantly associated with shorter overall survival (OS) and disease-free survival (DFS) of ESCC patients (both P< 0.001). Further multivariate analysis identified miR-15a as an independent prognostic factor for both OS and DFS (both P= 0.01).
conclusionDecreased expression of miR-15a may play a crucial role in ESCC development and progression. Serum miR-15a level could be used as a potential diagnostic and prognostic marker in clinics.
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