ArticleCancer biomarkers : section A of Disease markers2016
Prognostic factors for survival in advanced appendiceal cancers.
Article in Cancer biomarkers : section A of Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- A 20-Year Real-World Study of Small Bowel Cancers: Histologic Subtypes, Clinical Features, and Survival Implications.Journal of clinical medicine · 2025Article
- Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on low-grade appendiceal mucinous neoplasm: A single tertiary hospital experience.Journal of the Chinese Medical Association : JCMA · 2022Article
- Article
- Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer.Gastroenterology research and practice · 2020Article
- Epidemiology of and prognostic factors for appendiceal carcinomas: a retrospective, population-based study.International journal of colorectal disease · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAppendiceal cancer is a rare malignancy. The optimal pathologic classification and prognostic factors for survival and treatment strategies remain poorly understood.
objectiveThe aim of this retrospective cohort study was to determine prognostic factors, including markers of systemic inflammation, for survival in a cohort of patients with advanced appendiceal adenocarcinomas.
methodsThe study included patients with advanced appendiceal carcinoma that were treated between January 2006 and June 2012. The associations between age, gender, histopathologic subtype of appendiceal malignancy and treatment with heated intraperitoneal chemotherapy (HIPEC) and overall survival (OS) were assessed. The relationship between various markers of inflammation (platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio) and OS was also evaluated.
resultsA total of 49 patients met eligibility criteria. Female gender and low-grade adenocarcinoma were associated with increased OS. These data suggest that the use of HIPEC treatment may also be associated with improved OS, but the difference was not statistically significant (HR = 0.37 [0.12-1.18], p = 0.09). We found no evidence of an association between markers of inflammation at diagnosis and OS.
conclusionsHistopathologic subtype and gender are associated with OS in patients with advanced appendiceal carcinoma. Baseline platelet levels, NLR, and PLR do not appear to be predictive of OS in this setting.
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