ArticleOncotarget2017
Dynamic contrast-enhanced magnetic resonance imaging for pretreatment prediction of early chemo-radiotherapy response in larynx and hypopharynx carcinoma.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Routine restaging after primary non-surgical treatment of laryngeal squamous cell carcinoma-a review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Pooled it
- Concordance between head and neck MRI and histopathology in detecting laryngeal subsite invasion among patients with laryngeal cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters.European journal of radiology open · 2023Article
- Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI.Disease markers · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study is to investigate the use of dynamic contrast-enhanced magnetic resonance imaging in predicting early response to CRT (chemo-radiotherapy) in patients with larynx and hypopharynx carcinoma from primary tumors.
methodSixty-two patients with larynx and hypopharynx carcinoma underwent two DCE-MRI studies: a baseline exam before any treatmentanda post-treatment exam 3 weeks after CRT. At the end of treatment, patients were classified as responders, or non-responders according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST). The time intensity curves (TIC) were extracted and processed to obtain time to peak (TTP), maximum slope of increase (MSI), maximum slope of decrease (MSD) and positive enhancement integral (PEI), and the semi-quantitative MRI parameters were compared and analyzed between the two groups.
resultsFifty-four and 8 patients were included the responder and non-responder groups. It was observed that the MSI, MSD, and PEI were significantly lower post-treatment than pre-treatment(P < 0.05). The pretreatment MSI, MSD, and PEI parameters of responders were significantly higher than those of non-responders (P< 0.05). The post-treatment MSI, MSD, and PEI parameters of responders were significantly lower than those of non-responders (P< 0.05). Based on ROC curve analysis, at a threshold of 154.81 for pretreatment MSI, the corresponding AUC, sensitivity, and specificity were 0.882, 89.3% and 73.5%, respectively.
conclusionThe semi-quantitative DCE-MRI may aid in the prediction of early response to CRT in patients with larynx and hypopharynx carcinoma.
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