Evidence map›Paper›PMID 27802021›Full record

ArticleACS nano2016

Structure and Function of Iron-Loaded Synthetic Melanin.

Yiwen Li, Yijun Xie, Zhao Wang, Nanzhi Zang, Fabio Carniato, Yuran Huang, Christopher M Andolina, Lucas R Parent, Treffly B Ditri, Eric D Walter and 3 more

Abstract read
In one paragraph

Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. From melanogenesis to melanin technologies.Communications chemistry · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin forFrontiers in bioengineering and biotechnology · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yiwen LiCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University , Chengdu 610065, China.
Yijun Xie
Zhao Wang
Nanzhi Zang
Fabio CarniatoDipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "A. Avogadro" , Alessandria, Italy.
Yuran Huang
Christopher M AndolinaDepartment of Chemistry, University of Pittsburgh , 4200 Fifth Avenue, Pittsburgh, Pennsylvania 15260, United States.
Lucas R Parent
Treffly B Ditri
Eric D WalterInstitute for Integrated Catalysis, and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory , Richland, Washington 99354, United States.
Mauro BottaDipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "A. Avogadro" , Alessandria, Italy.
Jeffrey D Rinehart
Nathan C Gianneschi

Funding

In situ Liquid Cell Transmission Electron Microscopy (LCTEM) for Observing Tumor Responsive NanocarriersF32EB021859 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PARENT, LUCAS R. · 2016 to 2017
$77k
NIBIB NIH HHS F32 EB021859
6 · The paper itself

Abstract

We describe a synthetic method for increasing and controlling the iron loading of synthetic melanin nanoparticles and use the resulting materials to perform a systematic quantitative investigation on their structure-property relationship. A comprehensive analysis by magnetometry, electron paramagnetic resonance, and nuclear magnetic relaxation dispersion reveals the complexities of their magnetic behavior and how these intraparticle magnetic interactions manifest in useful material properties such as their performance as MRI contrast agents. This analysis allows predictions of the optimal iron loading through a quantitative modeling of antiferromagnetic coupling that arises from proximal iron ions. This study provides a detailed understanding of this complex class of synthetic biomaterials and gives insight into interactions and structures prevalent in naturally occurring melanins.

Indexed as

Contrast MediaElectron Spin Resonance SpectroscopyIronMagnetic Resonance ImagingMelaninsNanoparticlesContrast MediaIronMelaninsantiferromagnetic couplingmagnetometryMRIpolymerizationsynthetic melanin

Identifiers

PMID27802021
PMCPMC5295137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.