Trial reportJournal of the American Geriatrics Society2016
Self-Reported Sleep Apnea and Dementia Risk: Findings from the Prevention of Alzheimer's Disease with Vitamin E and Selenium Trial.
Trial report in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00040378 (Prevention of Alzheimer's Disease by Vitamin E and Selenium), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The role of APOE ε4 in modulating the relationship between non-genetic risk factors and dementia: a system review and meta-analysis.Journal of neurology · 2025Pooled it
- Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies.Journal of neurology · 2025Pooled it
- Are sleep disturbances modifiable risk factors for mild cognitive impairment and dementia? A systematic review of large studies.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.GeroScience · 2025Pooled it
- Association between sleep apnoea and risk of cognitive impairment and Alzheimer's disease: a meta-analysis of cohort-based studies.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Sleep-disordered breathing and the risk of cognitive decline: a meta-analysis of 19,940 participants.Sleep & breathing = Schlaf & Atmung · 2018Pooled it
- Sleep quality, APOE ε4, and Alzheimer's disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis.BMC medicine · 2025Article
- Shifting Perspectives on the Role of Tocotrienol vs. Tocopherol in Brain Health: A Scoping Review.International journal of molecular sciences · 2025Article
- Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity in REM sleep and verbal memory.Alzheimer's research & therapy · 2024Article
- Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease.Physiological reviews · 2024Review
- Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity and verbal memory.Research square · 2023Article
- Preventive Measures against the Development of Dementia in Old Age.Korean journal of family medicine · 2022Article
- Sleep disorders in Alzheimer's disease: the predictive roles and potential mechanisms.Neural regeneration research · 2021Review
- Obstructive Sleep Apnea and Cognitive Decline: A Review of Potential Vulnerability and Protective Factors.Brain sciences · 2021Review
- Mental Component Score (MCS) from Health-Related Quality of Life Predicts Incidence of Dementia in U.S. Males.The journal of prevention of Alzheimer's disease · 2021Article
- Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia.Journal of Alzheimer's disease : JAD · 2021Article
- Article
- Brain age from the electroencephalogram of sleep.Neurobiology of aging · 2019Article
- Obstructive Sleep Apnea and the Risk of Cognitive Decline in Older Adults.American journal of respiratory and critical care medicine · 2019Review
- Biomarkers of dementia in obstructive sleep apnea.Sleep medicine reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the association between baseline sleep apnea and risk of incident dementia in the Prevention of Alzheimer's Disease with Vitamin E and Selenium (PREADViSE) study and to explore whether the association depends on apolipoprotein E (APOE) ɛ4 allele status.
designSecondary analysis based on data collected during PREADViSE.
settingParticipants were assessed at 128 local clinical study sites during the clinical trial phase and later were followed by telephone from a centralized location.
participantsMen enrolled in PREADViSE (without dementia or other active neurological conditions that affect cognition such as major psychiatric disorders, including depression; N = 7,547). MEASUREMENTS: Participants were interviewed at baseline for sleep apnea. The Memory Impairment Screen (MIS) was administered to each participant annually. Subjects who failed this initial screen were tested with secondary screening tests. Medical history and medication use were determined, and the AD8 dementia screening instrument was used.
resultsThe effect of self-reported sleep apnea on dementia risk depended on APOE ɛ4 status. When the allele was absent, baseline self-reported sleep apnea was associated with a 66% higher risk of developing dementia (95% confidence interval = 2-170%), whereas self-reported sleep apnea conferred no additional risk for participants with an ɛ4 allele.
conclusionSleep apnea may increase risk of dementia in the absence of APOE ɛ4. This may help inform prevention strategies for dementia or AD in older men with sleep apnea. Registration: PREADViSE is registered at ClinicalTrials.gov: NCT00040378.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.