ArticleTranslational psychiatry2016
Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Upregulation of DNA repair-related genes in the prefrontal cortex of patients with schizophrenia with low genetic risk.Schizophrenia (Heidelberg, Germany) · 2026Article
- Ventricular cardiac magnetic resonance traits and schizophrenia risk: a UK Biobank and Mendelian randomization study.Frontiers in psychiatry · 2026Article
- Polygenic risk for neuroticism is associated with less efficient control in more difficult situations.Psychiatry research. Neuroimaging · 2023Article
- Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis.Translational psychiatry · 2023Article
- Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males.Molecular psychiatry · 2021Article
- Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls.Translational psychiatry · 2020Article
- A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation.Journal of psychiatric research · 2019Article
- A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.Human brain mapping · 2019Article
- Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study.The British journal of psychiatry : the journal of mental science · 2019Article
- Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP).Translational psychiatry · 2018Article
- Aspects of Additional Psychiatric Disorders in Severe Depression/Melancholia: A Comparison between Suicides and Controls and General Pattern.International journal of environmental research and public health · 2018Article
- Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Annual review of clinical psychology · 2018Review
- Genetics Factors in Major Depression Disease.Frontiers in psychiatry · 2018Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
Major depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of the personality trait neuroticism; factors also associated with schizophrenia (SCZ). It is possible that some cases of MDD may have a substantial genetic loading for SCZ. The presence of SCZ-like MDD subgroups would be indicated by an interaction between MDD status and polygenic risk of SCZ on cognitive, personality and mood measures. Here, we hypothesized that higher SCZ polygenic risk would define larger MDD case-control differences in cognitive ability, and smaller differences in distress and neuroticism. Polygenic risk scores (PRSs) for SCZ and their association with cognitive variables, neuroticism, mood and psychological distress were estimated in a large population-based cohort (Generation Scotland: Scottish Family Health Study, GS:SFHS). The individuals were divided into those with, and without, depression (n=2587 and n=16 764, respectively) to test for the interactions between MDD status and schizophrenia risk. Replication was sought in UK Biobank (UKB; n=6049 and n=27 476 cases and controls, respectively). In both the cohorts, we found significant interactions between SCZ-PRS and MDD status for measures of psychological distress (β
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.