Evidence map›Paper›PMID 27801892›Full record

ArticleTranslational psychiatry2016

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers.

A P Allen, W Hutch, Y E Borre, P J Kennedy, A Temko, G Boylan, E Murphy, J F Cryan, T G Dinan, G Clarke

Registry-linked trialOpen access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07752342 (Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™), which is not on this map. Cited by 252 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 9 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07752342 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™: a Prospective Open-Label Real-World Study

TypeinterventionalSponsorNovonesisRan2026 to 2027Enrolled150ConditionsHealthy Young AdultsArmsBifidobacterium longum, 1714™
3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 9 syntheses or guidelines pooled it, 493 citations in OpenAlex.

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  13. Intake ofNutrients · 2023
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  16. PsychobioticFrontiers in immunology · 2023
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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

A P AllenAPC Microbiome Institute, Biosciences Building, University College Cork, Cork, Ireland.
W HutchINFANT Research Centre, University College Cork, Cork, Ireland.
Y E BorreAPC Microbiome Institute, Biosciences Building, University College Cork, Cork, Ireland.
P J KennedyAPC Microbiome Institute, Biosciences Building, University College Cork, Cork, Ireland.
A TemkoDepartment of Electrical and Electronic Engineering, University College Cork, Cork, Ireland.
G BoylanINFANT Research Centre, University College Cork, Cork, Ireland.
E MurphyAlimentary Health Ltd., Cork Airport Business Park, Cork, Ireland.
J F CryanAPC Microbiome Institute, Biosciences Building, University College Cork, Cork, Ireland.
T G DinanAPC Microbiome Institute, Biosciences Building, University College Cork, Cork, Ireland.
G ClarkeAPC Microbiome Institute, Biosciences Building, University College Cork, Cork, Ireland.
University College Cork · IEAPC Microbiome Institute · IEAlimentary Health (Ireland) · IEInfant · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging concept of psychobiotics-live microorganisms with a potential mental health benefit-represents a novel approach for the management of stress-related conditions. The majority of studies have focused on animal models. Recent preclinical studies have identified the B. longum 1714 strain as a putative psychobiotic with an impact on stress-related behaviors, physiology and cognitive performance. Whether such preclinical effects could be translated to healthy human volunteers remains unknown. We tested whether psychobiotic consumption could affect the stress response, cognition and brain activity patterns. In a within-participants design, healthy volunteers (N=22) completed cognitive assessments, resting electroencephalography and were exposed to a socially evaluated cold pressor test at baseline, post-placebo and post-psychobiotic. Increases in cortisol output and subjective anxiety in response to the socially evaluated cold pressor test were attenuated. Furthermore, daily reported stress was reduced by psychobiotic consumption. We also observed subtle improvements in hippocampus-dependent visuospatial memory performance, as well as enhanced frontal midline electroencephalographic mobility following psychobiotic consumption. These subtle but clear benefits are in line with the predicted impact from preclinical screening platforms. Our results indicate that consumption of B. longum 1714 is associated with reduced stress and improved memory. Further studies are warranted to evaluate the benefits of this putative psychobiotic in relevant stress-related conditions and to unravel the mechanisms underlying such effects.

Indexed as

Bifidobacterium longumTranslational Research, BiomedicalAdultArousalBrainCase-Control StudiesCognition DisordersCold TemperatureElectroencephalographyFemaleHippocampusHumansHydrocortisoneMaleMental RecallNeuropsychological TestsHydrocortisone

Identifiers

PMID27801892
PMCPMC5314114
OpenAlexW2546849981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.