Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Exercise-Driven NRF2 Activation as a Systemic Neuroprotective Strategy: Integrating Redox Biology, Muscle-Brain Crosstalk, and Therapeutic Targeting in Neurodegeneration.Biochemical genetics · 2026
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2. Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways.International journal of molecular sciences · 2025
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3. Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study.Frontiers in psychology · 2023
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4. Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories.Frontiers in psychiatry · 2023
   Review
5. Polysaccharides fromOxidative medicine and cellular longevity · 2022
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6. Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer's Disease.Cells · 2021
   Review
7. Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF.Acta pharmacologica Sinica · 2019
   Article
8. GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.Journal of experimental & clinical cancer research : CR · 2019
   Article
9. Ischaemic and hypoxic conditioning: potential for protection of vital organs.Experimental physiology · 2019
   Review
10. Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy.Frontiers in cellular neuroscience · 2019
    Article
11. Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone.The international journal of neuropsychopharmacology · 2018
    Article
12. Normal glutathione levels in autopsied brain of chronic users of heroin and of cocaine.Drug and alcohol dependence · 2018
    Article
13. Dl-3-n-Butylphthalide improves lipopolysaccharide-induced depressive-like behavior in rats: involvement of Nrf2 and NF-κB pathways.Psychopharmacology · 2018
    Article
14. Peripheral Administration of Tetanus Toxin Hc Fragment Prevents MPPNeurotoxicity research · 2018
    Article
15. Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression.Oxidative medicine and cellular longevity · 2018
    Article
16. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017
    Article
17. The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway.Scientific reports · 2017
    Article
18. Low β2 Main Peak Frequency in the Electroencephalogram Signs Vulnerability to Depression.Frontiers in neuroscience · 2016
    Article
19. Effects of Single Cage Housing on Stress, Cognitive, and Seizure Parameters in the Rat and Mouse Pilocarpine Models of Epilepsy.eNeuro
    Article

Corrections and comments

• Erratum for
  Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression.2017

Authors and funding

12 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract