Evidence map›Paper›PMID 27801875›Full record

ReviewMolecules (Basel, Switzerland)2016

Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress.

Annia Galano, Romina Castañeda-Arriaga, Adriana Pérez-González, Dun-Xian Tan, Russel J Reiter

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Serotonergic Regulation in Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Metagenomic-Metabolomic Mining ofFrontiers in microbiology · 2022
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Annia GalanoDepartamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico. agal@xanum.uam.mx.
Romina Castañeda-ArriagaDepartamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico. animor_ca@hotmail.com.
Adriana Pérez-GonzálezConsejo Nacional de Ciencia y Tecnología (CONACYT)-Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico. adriana_perez_3@hotmail.com.
Dun-Xian TanDepartment of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA. Tan@uthscsa.edu.
Russel J ReiterDepartment of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA. REITER@uthscsa.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is currently no doubt about the serious threat that oxidative stress (OS) poses to human health. Therefore, a crucial strategy to maintain a good health status is to identify molecules capable of offering protection against OS through chemical routes. Based on the known efficiency of the phenolic and melatonin (MLT) families of compounds as antioxidants, it is logical to assume that phenolic MLT-related compounds should be (at least) equally efficient. Unfortunately, they have been less investigated than phenols, MLT and its non-phenolic metabolites in this context. The evidence reviewed here strongly suggests that MLT phenolic derivatives can act as both primary and secondary antioxidants, exerting their protection through diverse chemical routes. They all seem to be better free radical scavengers than MLT and Trolox, while some of them also surpass ascorbic acid and resveratrol. However, there are still many aspects that deserve further investigations for this kind of compounds.

Indexed as

AnimalsAntioxidantsChromansFree Radical ScavengersHumansMelatoninOxidative StressPhenols6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acidAntioxidantsChromansFree Radical ScavengersMelatoninPhenolsfree radicalskineticsmetal chelationreaction mechanismsscavenging activitytrends in activity

Identifiers

PMID27801875
PMCPMC6274579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.