Evidence map›Paper›PMID 27801835›Full record

ArticleNutrients2016

Dietary Gluten-Induced Gut Dysbiosis Is Accompanied by Selective Upregulation of microRNAs with Intestinal Tight Junction and Bacteria-Binding Motifs in Rhesus Macaque Model of Celiac Disease.

Mahesh Mohan, Cheryl-Emiliane T Chow, Caitlin N Ryan, Luisa S Chan, Jason Dufour, Pyone P Aye, James Blanchard, Charles P Moehs, Karol Sestak

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  19. Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies.International journal of molecular sciences · 2020
    Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mahesh MohanDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA. mmohan@tulane.edu.
Cheryl-Emiliane T ChowSecond Genome Inc., San Francisco, CA 94080, USA. cheryl@secondgenome.com.
Caitlin N RyanSecond Genome Inc., San Francisco, CA 94080, USA. caitlin@secondgenome.com.
Luisa S ChanSecond Genome Inc., San Francisco, CA 94080, USA. luisa@secondgenome.com.
Jason DufourDivision of Veterinary Resources, Tulane National Primate Research Center, Covington, LA 70433, USA. jdufour@tulane.edu.
Pyone P AyeDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA. paye@tulane.edu.
James BlanchardDivision of Veterinary Resources, Tulane National Primate Research Center, Covington, LA 70433, USA. jblanch1@tulane.edu.
Charles P MoehsArcadia Biosciences Inc., Seattle, WA 98119, USA. max.moehs@arcadiabio.com.
Karol SestakDivision of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA. ksestak@tulane.edu.
Tulane University · USSecond Genome (United States) · USArcadia Biosciences (United States) · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Role of microRNAs in B-cell dysfunction in HIV/SIV infectionR01DA042524 · NIDA · TULANE UNIVERSITY OF LOUISIANA · PI MOHAN, MAHESH · 2016 to 2020
$4.2M
Research Training in Experimental Medicine and PathologyT32OD011124 · OD · TULANE UNIVERSITY OF LOUISIANA · PI BLAIR, ROBERT, RAPPAPORT, JAY · 2012 to 2019
$2.7M
Reduced gluten cereal grainsR42DK097976 · NIDDK · ARCADIA BIOSCIENCES, INC. · PI VAN BOXTEL, JOS H · 2013 to 2016
$2.0M
Molecular Pathology of HIV/SIV EnteropathyR01DK083929 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI MOHAN, MAHESH · 2010 to 2014
$1.7M
NIDA NIH HHS R01 DA042524NIDDK NIH HHS R01 DK083929NIDDK NIH HHS R42 DK097976NIH HHS P51 OD011104NIH HHS T32 OD011124
6 · The paper itself

Abstract

The composition of the gut microbiome reflects the overall health status of the host. In this study, stool samples representing the gut microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those from 6 healthy, age- and diet-matched peers. A total of 48 samples representing both groups were studied using V4 16S rRNA gene DNA analysis. Samples from GS macaques were further characterized based on type of diet administered: conventional monkey chow, i.e., wheat gluten-containing diet (GD), gluten-free diet (GFD), barley gluten-derived diet (BOMI) and reduced gluten barley-derived diet (RGB). It was hypothesized that the GD diet would lower the gut microbial diversity in GS macaques. This is the first report illustrating the reduction of gut microbial alpha-diversity (

Indexed as

Disease Models, AnimalAnimalsBiomarkersCeliac DiseaseClaudin-1DysbiosisFecesFemaleGastrointestinal MicrobiomeGene Expression RegulationGlutensIntestinal MucosaJejunumMacaca mulattaMaleMicroRNAsBiomarkersClaudin-1GlutensMicroRNAsPlant Proteins, DietaryRNA, BacterialRNA, Ribosomal, 16S16S rRNAceliacchronic inflammationdysbiosisglutengutmacaquemetagenomicsmicrobiomemicrobiotamiRNArhesus

Identifiers

PMID27801835
PMCPMC5133072
OpenAlexW2540055555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.