Evidence map›Paper›PMID 27801817›Full record

ArticleMetabolites2016

Partial Least Squares with Structured Output for Modelling the Metabolomics Data Obtained from Complex Experimental Designs: A Study into the Y-Block Coding.

Yun Xu, Howbeer Muhamadali, Ali Sayqal, Neil Dixon, Royston Goodacre

Abstract read
In one paragraph

Article in Metabolites, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yun XuSchool of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK. yun.xu-2@manchester.ac.uk.
Howbeer MuhamadaliSchool of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK. howbeer.muhamadali@manchester.ac.uk.
Ali SayqalSchool of Chemistry, Umm Al-Qura University, Al Taif Road, Mecca 24382, Saudi Arabia. aasayqal@uqu.edu.sa.
Neil DixonSchool of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK. Neil.Dixon@manchester.ac.uk.
Royston GoodacreSchool of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK. roy.goodacre@manchester.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/C519038/1Biotechnology and Biological Sciences Research Council BB/M017702/1
6 · The paper itself

Abstract

Partial least squares (PLS) is one of the most commonly used supervised modelling approaches for analysing multivariate metabolomics data. PLS is typically employed as either a regression model (PLS-R) or a classification model (PLS-DA). However, in metabolomics studies it is common to investigate multiple, potentially interacting, factors simultaneously following a specific experimental design. Such data often cannot be considered as a "pure" regression or a classification problem. Nevertheless, these data have often still been treated as a regression or classification problem and this could lead to ambiguous results. In this study, we investigated the feasibility of designing a hybrid target matrix

Indexed as

experimental designmetabolomicspartial least squaresstructural modellingY coding

Identifiers

PMID27801817
PMCPMC5192444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.