Evidence map›Paper›PMID 27801816›Full record

ArticleMarine drugs2016

Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β.

Jutta Wiese, Johannes F Imhoff, Tobias A M Gulder, Antje Labes, Rolf Schmaljohann

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Marine-Derived Polyketides fromACS pharmacology & translational science · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jutta WieseGEOMAR Helmholtz Center for Ocean Research Kiel, Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. jwiese@geomar.de.
Johannes F ImhoffGEOMAR Helmholtz Center for Ocean Research Kiel, Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. jimhoff@geomar.de.
Tobias A M GulderBiosystems Chemistry, Department of Chemistry and Center for Integrated Protein Science Munich (CISPM), Technical University of Munich, Lichtenbergstraße 4, 85748 Garching, Germany. tobias.gulder@ch.tum.de.
Antje LabesGEOMAR Helmholtz Center for Ocean Research Kiel, Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. alabes@geomar.de.
Rolf SchmaljohannGEOMAR Helmholtz Center for Ocean Research Kiel, Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. rschmaljohann@geomar.de.
GEOMAR Helmholtz Centre for Ocean Research Kiel · DECenter for Integrated Protein Science Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme is involved in the signaling pathways of type 2 diabetes, neurological disorders, cancer, and other diseases. Therefore, inhibitors of GSK-3 are promising drug candidates for the treatment of a broad range of diseases. Here we report pannorin (

Indexed as

CoumarinsDrug DiscoveryEnzyme InhibitorsFungiGlycogen Synthase Kinase 3 betaLactonesNaphtholsProtein Kinase InhibitorsPyronesSignal TransductionThiadiazoles4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dionealternariolalternariol monomethyl etherCoumarinsEnzyme InhibitorsGlycogen Synthase Kinase 3 betaLactonesNaphtholspannorinProtein Kinase InhibitorsPyronesThiadiazolesalternariolalternariol-9-methyl etherAspergillusBotrytiniadeep-seaGSK-3βpannorin

Identifiers

PMID27801816
PMCPMC5128743
OpenAlexW2543382862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.