Trial reportNutrients2016
Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial.
Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Maternal Dadiah (Minangkabau Yogurt) Supplementation During Pregnancy on Child Growth, Gut Microbiota Proportion and the Level of Secretory Immunoglobulin A, in West Sumatra: A Randomised Clinical Trial
The Effect of Foot Massage and Maternal Heart Sound on Colic and Comfort Levels in Infants With Infantile Colic
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Probiotics for preventing and treating infant regurgitation: A systematic review and meta-analysis.Maternal & child nutrition · 2022Pooled it
- Reporting of Perinatal Outcomes in Probiotic Randomized Controlled Trials. A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease.Nutrients · 2020Pooled it
- Probiotics to prevent infantile colic.The Cochrane database of systematic reviews · 2019Pooled it
- The Effect of Lactobacillus Acidophilus (La5) on the Incidence of Urinary Tract Infection in the Puerperium: A Randomized Placebo-Controlled Trial.Probiotics and antimicrobial proteins · 2026Trial
- Effect of Supplementation withNutrients · 2026Trial
- The Effect of Probiotics on Health in Pregnancy and Infants: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2025Trial
- Effects of probiotics on gastrointestinal symptoms, anthropometric measurements, and breastfeeding duration in infants with colic: a randomized control trial.Sao Paulo medical journal = Revista paulista de medicina · 2024Trial
- The efficacy of the prenatal administration of Lactobacillus reuteri LR92 DSM 26866 on the prevention of infantile colic: a randomized control trial.European journal of pediatrics · 2020Trial
- Trial
- Effect of Probiotics on the Gut-Mammary Pathway: Implications on Infant Microbiota Transfer and Development.Current nutrition reports · 2026Review
- Human milk microbiota: origins, determinants, and roles in maternal-infant microbial transmission and infant microbiome assembly.Frontiers in microbiology · 2026Review
- Fish oil and probiotic food supplements: consumptions and attitudes of pregnant women in four European countries.European journal of nutrition · 2025Article
- Early-Life Supplementation Enhances Gastrointestinal Immunity and Microbiota in Young Rats.Foods (Basel, Switzerland) · 2024Article
- Article
- [Research status and prospects of probiotics in functional gastrointestinal disorders in infants and toddlers].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Influence of connatural factors in shaping vaginal microflora and ensuring its health.Archives of gynecology and obstetrics · 2024Review
- A Mini Literature Review of Probiotics: Transforming Gastrointestinal Health Through Evidence-Based Insights.Cureus · 2024Review
- Impact of maternalFrontiers in immunology · 2024Article
- Maternal oral probiotic use is associated with decreased breastmilk inflammatory markers, infant fecal microbiome variation, and altered recognition memory responses in infants-a pilot observational study.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProbiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants.
aimThe aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and lactation on cytokine profile and secretory IgA (sIgA) in breast milk and thus to study if differences in breast milk composition can affect lactoferrin and sIgA levels in stool samples of newborns. The safety of maternal probiotic administration on neonatal growth pattern and gastrointestinal symptoms were also evaluated.
methodsIn a double-blind, placebo-controlled, randomized trial, 66 women took either the probiotic (
resultsProbiotic maternal consumption had a significant impact on IL6 mean values in colostrum and on IL10 and TGF-β1 mean values in mature breast milk. Fecal sIgA mean values were higher in newborns whose mothers took the probiotic product than in the control group. Probiotic maternal supplementation seems to decrease incidence of infantile colic and regurgitation in infants.
conclusionHigh-dose multi-strain probiotic administration to women during pregnancy influences breast milk cytokines pattern and sIgA production in newborns, and seems to improve gastrointestinal functional symptoms in infants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.