NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

32 citing papers in PubMed.

1. The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities.MedComm · 2026
   Review
2. NLRP3 inflammasome in acute kidney injury: molecular mechanisms, post-translational regulation, and immunotherapeutic potential.Frontiers in immunology · 2026
   Review
3. Type I interferon production in myeloid cells is regulated by factors independent of Ptpn22.ImmunoHorizons · 2025
   Article
4. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation.Metabolic brain disease · 2024
   Article
5. Fantastic voyage: The journey of NLRP3 inflammasome activation.Genes & diseases · 2024
   Review
6. Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
   Review
7. Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders.Nature reviews. Drug discovery · 2023
   Review
8. Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model.Nature communications · 2023
   Article
9. A phospho-harmonic orchestra plays the NLRP3 score.Frontiers in immunology · 2023
   Review
10. The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis.International journal of medical sciences · 2022
    Review
11. Activation and Regulation of NLRP3 by Sterile and Infectious Insults.Frontiers in immunology · 2022
    Review
12. Walking down Skeletal Muscle Lane: From Inflammasome to Disease.Cells · 2021
    Review
13. Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages.Cellular & molecular immunology · 2021
    Article
14. TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
15. Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.Microbiology spectrum · 2021
    Article
16. Genotype-phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients.BMC gastroenterology · 2021
    Article
17. Overexpression of theJournal of immunology (Baltimore, Md. : 1950) · 2021
    Article
18. De-coding genetic risk variants in type 1 diabetes.Immunology and cell biology · 2021
    Review
19. The Role of Protein Tyrosine Phosphatases in Inflammasome Activation.International journal of molecular sciences · 2020
    Review
20. Short Exposure to Ethanol Diminishes Caspase-1 and ASC Activation in Human HepG2 Cells In Vitro.International journal of molecular sciences · 2020
    Article

Corrections and comments

• Erratum for
  NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.2016

Authors and funding

22 authors.

Funding

Abstract

PubMed holds no abstract for this paper.