ReviewOncotarget2017
FDA-approved medications that impair human spermatogenesis.
Review in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- A case of secretory azoospermia: is valganciclovir responsible?Basic and clinical andrology · 2026Article
- Naproxen and Ibuprofen Exposure Alter the Blood-Testis Barrier in a Novel In Vitro Model.International journal of molecular sciences · 2026Article
- Does coenzyme Q10 protect testicular function and spermatogenesis in rats receiving levofloxacin-containing therapy?Clinical and experimental reproductive medicine · 2026Article
- Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases.Frontiers in pharmacology · 2026Article
- Methoxsalen deteriorative effects on the testicular parenchyma and testosterone synthesis gene expression in male rats.Scientific reports · 2025Article
- Decrease or increase in sperm concentration? The data among fertile Chinese males in 40 years.Journal of assisted reproduction and genetics · 2025Article
- Fenofibrate ameliorated atorvastatin and piperine-induced ROS mediated reproductive toxicity in male Wistar rats.Toxicology reports · 2025Article
- Ameliorative effects of vitamin C and garlic (Frontiers in veterinary science · 2025Article
- The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan's National Health Insurance Research Database.European journal of medical research · 2024Article
- Improving human sperm motility via red and near-infrared laser irradiation: in-vitro study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- The temporary impact of COVID-19 on semen deoxyribonucleic acid fragmentation.Central European journal of urology · 2024Article
- The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening.Biomedicines · 2023Article
- Male infertility.Nature reviews. Disease primers · 2023Review
- Severe deterioration in sperm parameters and testes of rats administered naproxen and diclofenac at pre-puberty: An experimental study.International journal of reproductive biomedicine · 2022Article
- The Fate of Leydig Cells in Men with Spermatogenic Failure.Life (Basel, Switzerland) · 2022Review
- Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review.Journal of lasers in medical sciences · 2022Review
- Olanzapine induced reproductive toxicity in male rats.Scientific reports · 2021Article
- Onset of azoospermia in man treated with ipilimumab/nivolumab for BRAF negative metastatic melanoma.Urology case reports · 2021Article
- In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway.Heliyon · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official website for FDA-approved drug labels. Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. Overall, there were a total of 65 labels for drugs of various classes that showed that they have the potential to affect human sperm production and maturation. We identified several drugs indicated to be spermatotoxic in the drug labels that were not reported in the peer-reviewed literature. However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. Therefore, additional work is needed at both the basic research level and during clinical trials and post-marketing surveillance to fill the gaps in the current knowledge. The present findings will be of interest to physicians and pharmacists, researchers, and those involved in drug development and health care policy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.