ArticleRNA biology2017
The mRNA transportome of the BicD/Egl transport machinery.
Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- AnbioRxiv : the preprint server for biology · 2026Article
- Cytoplasmic localization of the mRNA encoding actin regulator, Serendipity-bioRxiv : the preprint server for biology · 2025Article
- Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging.PloS one · 2025Article
- Article
- Role of BicDR in bristle shaft construction and support of BicD functions.Journal of cell science · 2024Article
- The dynamic duo of microtubule polymerase Mini spindles/XMAP215 and cytoplasmic dynein is essential for maintainingProceedings of the National Academy of Sciences of the United States of America · 2023Article
- An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport.The Journal of cell biology · 2023Article
- Article
- Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.PLoS genetics · 2023Article
- dTtc1, a conserved tetratricopeptide repeat protein, is required for maturation ofFrontiers in cell and developmental biology · 2023Article
- Subcellular spatial transcriptomics identifies three mechanistically different classes of localizing RNAs.Nature communications · 2022Article
- Dynamics of maternal gene expression in Rhodnius prolixus.Scientific reports · 2022Article
- Optimal RNA binding by Egalitarian, a Dynein cargo adaptor, is critical for maintaining oocyte fate inRNA biology · 2021Article
- In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.Development (Cambridge, England) · 2021Article
- Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.Developmental biology · 2021Article
- Walking the line: mechanisms underlying directional mRNA transport and localisation in neurons and beyond.Cellular and molecular life sciences : CMLS · 2021Review
- A binding protein regulates myosin-7a dimerization and actin bundle assembly.Nature communications · 2021Article
- TheGenetics · 2019Article
- The Egalitarian binding partners Dynein light chain and Bicaudal-D act sequentially to link mRNA to the Dynein motor.Development (Cambridge, England) · 2019Article
- In-frame de novo mutation inCold Spring Harbor molecular case studies · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
mRNA (mRNA) transport focuses the expression of encoded proteins to specific regions within cells providing them with the means to assume specific functions and even identities. BicD and the mRNA binding protein Egl interact with the microtubule motor dynein to localize mRNAs in Drosophila. Because relatively few mRNA cargos were known, we isolated and identified Egl::GFP associated mRNAs. The top candidates were validated by qPCR, in situ hybridization and genetically by showing that their localization requires BicD. In young embryos these Egl target mRNAs are preferentially localized apically, between the plasma membrane and the blastoderm nuclei, but also in the pole plasm at the posterior pole. Egl targets expressed in the ovary were mostly enriched in the oocyte and some were apically localized in follicle cells. The identification of a large group of novel mRNAs associated with BicD/Egl points to several novel developmental and physiological functions of this dynein dependent localization machinery. The verified dataset also allowed us to develop a tool that predicts conserved A'-form-like stem loops that serve as localization elements in 3'UTRs.
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