ArticleACS central science2016
High-Throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals.
Article in ACS central science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
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- Mapping Biomaterial Complexity by Machine Learning.Tissue engineering. Part A · 2024Review
- Spray-dried nanocrystal-loaded polymer microparticles for long-term release local therapies: an opportunity for poorly soluble drugs.Drug delivery · 2023Article
- Discovery of Kinetic Trapping of Poloxamers inside Liposomes via Thermal Treatment.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies and Evaluation Approaches.Molecules (Basel, Switzerland) · 2023Review
- Random Heteropolymer Excipients Improve the Colloidal Stability of a Monoclonal Antibody for Subcutaneous Administration.Pharmaceutical research · 2023Article
- A fully automated platform for photoinitiated RAFT polymerization.Digital discovery · 2023Article
- Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance.Pharmaceutics · 2022Review
- Effective Industry-Academia Collaboration Driving Polymer Innovation.ACS polymers Au · 2022Review
- Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice.Nanomaterials (Basel, Switzerland) · 2021Article
- Automation and data-driven design of polymer therapeutics.Advanced drug delivery reviews · 2021Review
- Automated PET-RAFT Polymerization Towards Pharmaceutical Amorphous Solid Dispersion Development.ACS applied polymer materials · 2021Article
- High-throughput preparation of radioprotective polymers via Hantzsch's reaction for in vivo X-ray damage determination.Nature communications · 2020Article
- An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients.Science translational medicine · 2020Article
- Automation of Controlled/Living Radical Polymerization.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2020Article
- High-Throughput Preparation of Antibacterial Polymers from Natural Product Derivatives via the Hantzsch Reaction.iScience · 2020Article
- Article
- High-Throughput Tertiary Amine Deoxygenated Photopolymerizations for Synthesizing Polymer Libraries.Macromolecules · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymeric excipients are crucial ingredients in modern pills, increasing the therapeutic bioavailability, safety, stability, and accessibility of lifesaving products to combat diseases in developed and developing countries worldwide. Because many early-pipeline drugs are clinically intractable due to hydrophobicity and crystallinity, new solubilizing excipients can reposition successful and even failed compounds to more effective and inexpensive oral formulations. With assistance from high-throughput controlled polymerization and screening tools, we employed a strategic, molecular evolution approach to systematically modulate designer excipients based on the cyclic imide chemical groups of an important (yet relatively insoluble) drug phenytoin. In these acrylamide- and methacrylate-containing polymers, a synthon approach was employed: one monomer served as a precipitation inhibitor for phenytoin recrystallization, while the comonomer provided hydrophilicity. Systems that maintained drug supersaturation in amorphous solid dispersions were identified with molecular-level understanding of noncovalent interactions using NOESY and DOSY NMR spectroscopy. Poly(
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.