Evidence map›Paper›PMID 27800541›Full record

ArticleEmergency (Tehran, Iran)2016

Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial.

Gholamreza Faridaalaee, Neda Mohammadi, Seyedeh Zahra Merghati, Fatemeh Keyghobadi Khajeh, Bahman Naghipour, Mahboob Pouraghaei, Sajjad Ahmadi

Open access · greenAbstract read

PubMed Full text at PMC

In one paragraph

Article in Emergency (Tehran, Iran), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed, 2 pooled it

1.3field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

Exploring the Efficacy and Safety of Ketamine for Managing Acute Renal Colic in Emergency Departments: A Systematic Review of Recent Clinical Trials.International journal of molecular sciences · 2025
Pooled it
Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials.Frontiers in pharmacology · 2019
Pooled it
Treatment of reno-ureteral colic by twelfth intercostal nerve block with lidocaine versus intramuscular diclofenac.International urology and nephrology · 2017
Trial
Efficacy and Safety of Ketamine Versus Opiates in the Treatment of Patients with Renal Colic: A Systematic Review and Meta-analysis.Pain and therapy · 2023
Article
Comparison of Ketamine and Tramadol in Management of Acute Pain; a Systematic Review.Archives of academic emergency medicine · 2020
Review
Morphine-induced supraventricular tachycardia in near-term fetus.Italian journal of pediatrics · 2018
Article
Efficacy and Safety of Combination Therapy with Ketorolac and Morphine in Patient with Acute Renal Colic; A Triple-Blind Randomized Controlled Clinical Trial.Bulletin of emergency and trauma · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gholamreza FaridaalaeeEmergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, Iran.

Neda MohammadiEmergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran.

Seyedeh Zahra MerghatiInternational branch of Urmia University of Medical Sciences, Urmia, Iran.

Fatemeh Keyghobadi KhajehDepartment of Community Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Bahman NaghipourAnesthesiology Department, Tabriz University of Medical Sciences, Tabriz, Iran.

Mahboob PouraghaeiDepartment of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Sajjad AhmadiEmergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, Iran.

Tabriz University of Medical Sciences · IRUniversity of Maragheh · IRUrmia University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe main purpose of emergency department (ED) management for renal colic is prompt pain relief. The present study aimed to compare the analgesic effects of intravenus (IV) ketofol with morphine in management of ketorolac persistent renal colic.

methodsThis study is a single blind randomized, clinical trial, on patients who were presented to ED with renal colic, whose pain was resistant to 30 mg IV ketorolac. The patients were randomly assigned to either IV morphine (0.1 mg/kg) or IV ketofol (0.75 mg/kg propofol and 0.75 mg/kg) and the measures of treatment efficacy were compared between the groups after 5 and 10 minutes.

results90 patients with mean age of 38.01 ± 9.78 years were randomly divided into 2 groups of 45 (66.7% male). Treatment failure rate was significantly lower in ketofol group after 5 (20% vs 62.2%, p < 0.001) and 10 minutes (11.1% vs 44.4%, p < 0.001). ARR and NNT for ketofol after 5 miutes were 42.22% (95% CI: 23.86 - 60.59) and 3 (95% CI: 1.7 - 4.2), respectively. After 10 minutes, these measures reached 33.33 (95% CI:16.16 - 50.51) and 4 (95% CI: 2.0 - 6.2), respectively. NNH and ARI for hallucination or agitation were 12 (95%CI: 5.8 - 174.2) and 8.89% (0.57 - 17.20), respectively.

conclusionThe results of the present study, showed the significant superiority of ketofol (NNT at 5 minute = 3 and NNT at 10 minute = 4) in ketorolac resistant renal colic pain management. However, its NNH of 12, could limit its routine application in ED for this purpose.

Indexed as

ketaminemorphinepainpropofolRenal colic

Identifiers

PMID27800541

PMCPMC5007912

OpenAlexW2337872893

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.