Evidence map›Paper›PMID 27800151›Full record

ArticleChemical science2016

Tunable Helicity, Stability and DNA-Binding Properties of Short Peptides with Hybrid Metal Coordination Motifs.

Sarah J Smith, Robert J Radford, Rohit H Subramanian, Brandon R Barnett, Joshua S Figueroa, F Akif Tezcan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah J SmithDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Mia, USA.
Robert J RadfordDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Mia, USA.
Rohit H SubramanianDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Mia, USA.
Brandon R BarnettDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Mia, USA.
Joshua S FigueroaDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Mia, USA.
F Akif TezcanDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Mia, USA.
University of California, San Diego · USUniversity of California System · US

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Chemical Biology Interfaces at UC San DiegoT32GM112584 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2015 to 2019
$729k
Tetrahedral Ni Complexes as Acetyl-CoA Synthase ModelsF32GM074410 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI FIGUEROA, JOSHUA S · 2005 to 2006
$88k
NIGMS NIH HHS F32 GM074410NIGMS NIH HHS T32 GM008326NIGMS NIH HHS T32 GM112584
6 · The paper itself

Abstract

Given the prevalent role of α-helical motifs on protein surfaces in mediating protein-protein and protein-DNA interactions, there have been significant efforts to develop strategies to induce α-helicity in short, unstructured peptides to interrogate such interactions. Toward this goal, we have recently introduced hybrid metal coordination motifs (HCMs). HCMs combine a natural metal-binding amino acid side chain with a synthetic chelating group that are appropriately positioned in a peptide sequence to stabilize an α-helical conformation upon metal coordination. Here, we present a series of short peptides modified with HCMs consisting of a His and a phenanthroline group at

Identifiers

PMID27800151
PMCPMC5085262
OpenAlexW2397738695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.