ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2016
Predictors of allergen sensitization in Singapore children from birth to 3 years.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Prevalence and indoor environment risk factors of parent-reported food allergy symptoms among preschool children in Haikou City, China: a cross-sectional survey.Frontiers in public health · 2026Article
- Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population.The World Allergy Organization journal · 2025Article
- Clinical Characteristics of Infants Under Two Years of Age with Early Sensitization to House Dust Mites.Journal of clinical medicine · 2025Article
- Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children.Translational pediatrics · 2024Article
- Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.Frontiers in immunology · 2023Review
- Early Bronchiolitis Contributes to Preschool Asthma.Children (Basel, Switzerland) · 2021Article
- Atopic dermatitis trajectories to age 8 years in the GUSTO cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Article
- Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies.Bioscience reports · 2020Review
- Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy.Frontiers in immunology · 2020Review
- Shellfish/crustacean oral allergy syndrome among national service pre-enlistees in Singapore.Asia Pacific allergy · 2018Article
- The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundImmune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age.
objectiveTo determine the predictors of allergen sensitization in the first 3 years of life in the growing up in Singapore towards healthy outcomes (GUSTO) prospective birth cohort study.
methodsInterviewers collected information on demographics, family history of allergy, social and lifestyle factors, and the child's health. We analyzed data from 849 children who completed skin prick testing (SPT) to inhalant allergens (house dust mites:
resultsWe observed a significant association between eczema reported before 18 months and a positive SPT at 18 months [aOR 4.5 (1.9-10.7)]. Ninety-five (14.6 %) children with negative SPTs at 18 months developed positive tests at 36 months. Onset of eczema before 18 months was associated with an increased risk of new allergen sensitization at 36 months among children non-sensitized at 18 months [aOR 3.4 (1.2-9.3)]. An association was seen between wheeze reported before 18 months and new allergen sensitization at 36 months [aOR 3.2 (1.1-9.1)]. We found no significant association, however, between rhinitis reported before 18 months and new allergen sensitization at 36 months.
conclusionsEarly onset of eczema and wheeze are risk factors for later allergen sensitization, suggesting a possible increased susceptibility to allergen exposure through an impaired skin barrier or defective airway epithelium.
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