ArticleFrontiers in aging neuroscience2016
An Activation Likelihood Estimation Meta-Analysis Study of Simple Motor Movements in Older and Young Adults.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.Human brain mapping · 2017Trial
- Transcutaneous Vagus Nerve Stimulation During Motor Activity in Healthy Volunteers: A High-Density Diffuse Optical Tomography Study.Brain sciences · 2026Article
- Prefrontal cortex connectivity during right and left hand dexterity tests in younger and older adults.PloS one · 2026Article
- The ageing brain: Cortical overactivation - How does it evolve?The Journal of physiology · 2026Review
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Assessing age-related changes in brain activity during isometric upper and lower limb force control tasks.Brain structure & function · 2024Article
- Early motor skill acquisition in healthy older adults: brain correlates of the learning process.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Widespread fMRI BOLD Signal Overactivations during Cognitive Control in Older Adults Are Not Matched by Corresponding Increases in fPET Glucose Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- How the motor system copes with aging: a quantitative meta-analysis of the effect of aging on motor function control.Communications biology · 2022Review
- Deterioration, Compensation and Motor Control Processes in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2021Review
- Brain Activity and Functional Connectivity Patterns Associated With Fast and Slow Motor Sequence Learning in Late Middle Adulthood.Frontiers in aging neuroscience · 2021Article
- Task-Modulated Corticocortical Synchrony in the Cognitive-Motor Network Supporting Handwriting.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Model-Based and Model-Free Analyses of the Neural Correlates of Tongue Movements.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The functional neuroanatomy of finger movements has been characterized with neuroimaging in young adults. However, less is known about the aging motor system. Several studies have contrasted movement-related activity in older versus young adults, but there is inconsistency among their findings. To address this, we conducted an activation likelihood estimation (ALE) meta-analysis on within-group data from older adults and young adults performing regularly paced right-hand finger movement tasks in response to external stimuli. We hypothesized that older adults would show a greater likelihood of activation in right cortical motor areas (i.e., ipsilateral to the side of movement) compared to young adults. ALE maps were examined for conjunction and between-group differences. Older adults showed overlapping likelihoods of activation with young adults in left primary sensorimotor cortex (SM1), bilateral supplementary motor area, bilateral insula, left thalamus, and right anterior cerebellum. Their ALE map differed from that of the young adults in right SM1 (extending into dorsal premotor cortex), right supramarginal gyrus, medial premotor cortex, and right posterior cerebellum. The finding that older adults uniquely use ipsilateral regions for right-hand finger movements and show age-dependent modulations in regions recruited by both age groups provides a foundation by which to understand age-related motor decline and motor disorders.
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Registered trials
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