ArticleInternational journal of chronic obstructive pulmonary disease2016
Chronotropic incompetence can limit exercise tolerance in COPD patients with lung hyperinflation.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Heart rate recovery after the 6-min walk test in people with bronchiectasis.ERJ open research · 2025Article
- Respiratory muscle strength can improve the prognostic assessment in COPD.Scientific reports · 2024Article
- Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency.BMC pulmonary medicine · 2024Observational
- Chronotropic index during 6-minute walk and acute respiratory events in COPDGene.Respiratory medicine · 2022Article
- Chronotropic Incompetence in Non-Hospitalized Patients with Post-COVID-19 Syndrome.Journal of clinical medicine · 2021Article
- Chronotropic Index and Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Secondary Analysis of BLOCK COPD.Annals of the American Thoracic Society · 2021Article
- Cardiopulmonary exercise testing in patients with non-small cell lung cancer: trust the VJournal of thoracic disease · 2020Article
- Disconnection of pulmonary and systemic arterial stiffness in COPD.International journal of chronic obstructive pulmonary disease · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMetabolic-chronotropic relationship is the only concept that assesses the entire chronotropic function during exercise, as it takes into account individual fitness. To better understand interrelationships between chronotropic incompetence (CI), dynamic hyperinflation (DH) and exercise limitation among Global initiative for chronic Obstructive Lung Disease (GOLD) stages of chronic obstructive pulmonary disease (COPD) disease severity, we evaluated cardiopulmonary responses to symptom-limited cycle exercise in stable patients. PATIENTS AND
methodsWe prospectively studied 47 COPD patients classified by GOLD stage severity. Pulmonary function tests and cardiopulmonary responses to symptom-limited incremental exercise were studied. CI was defined by regression line between percent heart rate (HR) reserve and percent oxygen uptake (
resultsAerobic capacity (median interquartile ranges) peak
conclusionCOPD patients with DH have a poor cardiovascular response to exercise, which may be attributed to CI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.