ReviewDrug design, development and therapy2016
Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction.
Review in Drug design, development and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Choroidal and retinal alteration after long-term use of tadalafil: a prospective non-randomized clinical trial.Journal of basic and clinical physiology and pharmacology · 2024Trial
- Linoleyl acetate and mandenol alleviate HUA-induced ED via NLRP3 inflammasome and JAK2/STAT3 signalling conduction in rats.Journal of cellular and molecular medicine · 2024Article
- Case - Central serous retinopathy following topical intraurethral corticosteroid use for urethral stricture secondary to lichen sclerosus.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- Review
- Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.Stem cells translational medicine · 2022Article
- The ocular adverse effects of oral drugs.Australian prescriber · 2021Review
- A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6.The Journal of pharmacology and experimental therapeutics · 2021Article
- Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study.Diagnostics (Basel, Switzerland) · 2021Article
- Visual Side Effects Linked to Sildenafil Consumption: An Update.Biomedicines · 2021Review
- Central Serous Chorioretinopathy Following Oral Use of Adulterated Honey Mixed with Tadalafil: A Case Report.International medical case reports journal · 2021Article
- Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.Molecular cell · 2020Article
- Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation.Pharmaceutics · 2020Article
- Central Serous Chorioretinopathy in Elderly Patients Mimicking Occult Neovascular Age-Related Macular Degeneration.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Ocular Side Effects of Sildenafil That Persist Beyond 24 h-A Case Series.Frontiers in neurology · 2020Article
- Sildenafil/Viagra in the treatment of premature ejaculation.International journal of impotence research · 2019Review
- Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases.Science advances · 2019Article
- Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study.Journal of ophthalmology · 2017Article
- Effects of medications on the human electroretinogram: A comprehensive review.Survey of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this review was to summarize the ocular action of the most common phosphodiesterase (PDE) inhibitors used for the treatment of erectile dysfunction and the subsequent visual disorders.
methodThis is a literature review of several important articles focusing on the pathophysiology of visual disorders induced by PDE inhibitors.
resultsPDE inhibitors have been associated with ocular side effects, including changes in color vision and light perception, blurred vision, transient alterations in electroretinogram (ERG), conjunctival hyperemia, ocular pain, and photophobia. Sildenafil and tadalafil may induce reversible increase in intraocular pressure and be involved in the development of non-arteritic ischemic optic neuropathy. Reversible idiopathic serous macular detachment, central serous chorioretinopathy, and ERG disturbances have been related to the significant impact of sildenafil and tadalafil on retinal perfusion. DISCUSSION: So far, PDE inhibitors do not seem to cause permanent toxic effects on chorioretinal tissue and photoreceptors. However, physicians should write down any visual symptom observed during PDE treatment and refer the patients to ophthalmologists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.