Evidence map›Paper›PMID 27799647›Full record

Trial reportThe American journal of tropical medicine and hygiene2017

Low Immunogenicity of Recombinant Hepatitis B Vaccine Derived from Hansenula polymorpha in Adults Aged Over 40 Years.

Karlla Antonieta Amorim Caetano, Nativa Helena Alves Del-Rios, Raquel Silva Pinheiro, Fabiana Perez Rodrigues Bergamaschi, Megmar Aparecida Dos Santos Carneiro, Sheila Araujo Teles

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04540653 (Immunogenicity of the Hepatitis B Vaccine in Individuals 50 Years Old or More), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04540653 phase4unknown statusnot on this map

Immunogenicity of the Hepatitis B Vaccine in Individuals 50 Years Old or More: Randomized Clinical Trial

TypeinterventionalSponsorUniversidade Federal de GoiasRan2017 to 2022Enrolled240ConditionsVaccine Response Impaired, Hepatitis B, AgingArmsStandard vaccination schedule, Reinforced vaccination schedule
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Karlla Antonieta Amorim CaetanoNursing School, Federal University of Goias, Goiania, Brazil. karllacaetano@gmail.com.
Nativa Helena Alves Del-RiosInstitute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Brazil.
Raquel Silva PinheiroNursing School, Federal University of Goias, Goiania, Brazil.
Fabiana Perez Rodrigues BergamaschiNursing School, State University of Mato Grosso do Sul, Dourados, Brazil.
Megmar Aparecida Dos Santos CarneiroInstitute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Brazil.
Sheila Araujo TelesNursing School, Federal University of Goias, Goiania, Brazil.
Universidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Brazilian recombinant hepatitis B vaccine (VrHB-IB) is based on the expression of the recombinant antigen in Hansenula polymorpha yeast cells. Currently, data on the immunogenicity of this vaccine in older adults are nonexistent. This study aimed to evaluate the immunogenicity of VrHB-IB in adults over 40 years of age. From May to October 2011, 235 rural settlers between 2 and 93 years of age from the State of Goias in Brazil were eligible for vaccination. Of these, 180 accepted the first dose of the vaccine and 106 (58.9%) completed the vaccination schedule. Multivariate analysis revealed that individuals ≥ 40 years of age responded significantly less well to vaccination than younger adults. Also, a greater proportion of male nonresponders was observed (versus women; P = 0.02). These results point to the need for better evaluation of the immunogenicity of VrHB-IB in older adults.

Indexed as

AgingImmunogenicity, VaccineAdolescentAdultAgedAged, 80 and overBrazilChildChild, PreschoolFemaleHepatitis B AntibodiesHepatitis B VaccinesHumansInfantMaleMiddle AgedHepatitis B AntibodiesHepatitis B VaccinesRecombinant ProteinsVaccines, Synthetic

Identifiers

PMID27799647
PMCPMC5239676
OpenAlexW2541877017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.