Evidence map›Paper›PMID 27799632›Full record

ReviewThorax2016

Pulmonary fibrosis in the era of stratified medicine.

Susan K Mathai, Chad A Newton, David A Schwartz, Christine Kim Garcia

Open access · bronzeAbstract readReview
In one paragraph

Review in Thorax, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Assessing theRMD open · 2025
    Pooled it
  2. Systematic review of drug effects in humans and models with surfactant-processing disease.European respiratory review : an official journal of the European Respiratory Society · 2018
    Pooled it
  3. Review
  4. Review
  5. Genetic Associations in Non-Europeans with Pulmonary Fibrosis: Analysis of the All of Us Cohort.American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Lung transplant recipients with telomere-mediated pulmonary fibrosis have increased risk for hematologic complications.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  11. Proprotein Convertase Subtilisin/Kexin Type 6: A Risk Factor for Survival in Pulmonary Fibrosis?American journal of respiratory and critical care medicine · 2023
    Article
  12. Observational
  13. Article
  14. Aberrant Multiciliogenesis in Idiopathic Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2022
    Article
  15. Review
  16. Lung transplantation for idiopathic pulmonary fibrosis enriches for individuals with telomere-mediated disease.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  17. Article
  18. Observational
  19. Review
  20. Molecular Signatures of Idiopathic Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Susan K MathaiDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Chad A NewtonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
David A SchwartzDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Christine Kim GarciaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
The University of Texas Southwestern Medical Center · USUniversity of Colorado Denver · US

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6M
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4M
Pulmonary Fibrosis and Telomerase DysfunctionR01HL093096 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GARCIA, CHRISTINE KIM · 2009 to 2024
$6.9M
TRAINING PROGRAM IN LUNG BIOLOGY AND DISEASET32HL098040 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAUL, PHILIP W, TERADA, LANCE S · 2009 to 2024
$4.6M
MUC5B, a novel therapeutic target for Idiopathic Pulmonary Fibrosis (IPF)UH2HL123442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2014 to 2015
$3.0M
Functional Genetics in Idiopathic Pulmonary FibrosisR33HL120770 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2016 to 2018
$1.6M
Colorado Undergraduate Research in Environmental Health SciencesR25ES025476 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI ALISON K BAUER, Jared Michael Brown · 2015 to 2026
$1.3M
Functional Genetics in Idiopathic Pulmonary FibrosisR21HL120770 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2014 to 2015
$424k
Genetic and Epigenetic Changes in MUC5B and Fibrosing Interstitial Lung DiseaseI01BX001534 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI SCHWARTZ, DAVID ALBERT · 2013 to 2016
–
BLRD VA I01 BX001534NCATS NIH HHS UL1 TR001105NHLBI NIH HHS P01 HL092870NHLBI NIH HHS R01 HL093096NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R21 HL120770NHLBI NIH HHS R33 HL120770NHLBI NIH HHS T32 HL098040NHLBI NIH HHS UH2 HL123442NIEHS NIH HHS R25 ES025476
6 · The paper itself

Abstract

Both common and rare variants contribute to the genetic architecture of pulmonary fibrosis. Genome-wide association studies have identified common variants, or those with a minor allele frequency of >5%, that are linked to pulmonary fibrosis. The most widely replicated variant (rs35705950) is located in the promoter region of the

Indexed as

Genetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansLung Diseases, InterstitialMucin-5BPolymorphism, Single NucleotidePrecision MedicinePulmonary FibrosisPulmonary SurfactantsTelomere HomeostasisMucin-5BPulmonary SurfactantsIdiopathic pulmonary fibrosisInterstitial Fibrosis

Identifiers

PMID27799632
PMCPMC5450041
OpenAlexW2543970179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.