ArticleProceedings of the National Academy of Sciences of the United States of America2016
Genetic variants linked to education predict longevity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Pooled it
- Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.Nature genetics · 2018Pooled it
- Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics.PLoS genetics · 2025Article
- Multi-Polygenic prediction of Frailty and its Trajectories highlights Chronic Pain, Rheumatoid Arthritis, and Educational Attainment pathways.medRxiv : the preprint server for health sciences · 2025Article
- Multi-Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals.Journal of the American Heart Association · 2025Article
- Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Rapid discrimination between deleterious and benign missense mutations in the CAGI 6 experiment.Human genomics · 2024Article
- Polygenic Risk of Mental Disorders and Subject-Specific School Grades.Biological psychiatry · 2024Article
- Structural models of genome-wide covariance identify multiple common dimensions in autism.Nature communications · 2024Article
- The genetics of falling susceptibility and identification of causal risk factors.Scientific reports · 2023Article
- Which Factors Influence Healthy Aging? A Lesson from the Longevity Village of Bama in China.Aging and disease · 2023Review
- Does Children's Education Improve Parental Health and Longevity? Causal Evidence from Great Britain.Journal of health and social behavior · 2023Article
- Common huntingtin-related genetic variation is associated with neurobiological and aging traits in humans.Cell death discovery · 2022Article
- Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.Nature genetics · 2022Article
- High polygenic predisposition for ADHD and a greater risk of all-cause mortality: a large population-based longitudinal study.BMC medicine · 2022Article
- Causal relationship between educational attainment and the risk of rheumatoid arthritis: a Mendelian randomization study.BMC rheumatology · 2021Article
- Genes Related to Education Predict Frailty Among Older Adults in the United States.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Transpersonal Genetic Effects Among Older U.S. Couples: A Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.Scientific reports · 2020Article
- Polygenic predictors of age-related decline in cognitive ability.Molecular psychiatry · 2020Article
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22 authors.
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Abstract
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total n
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