Evidence map›Paper›PMID 27799335›Full record

ArticleInfection and immunity2017

Functional Impairment of Murine Dendritic Cell Subsets following Infection with Infective Larval Stage 3 of Brugia malayi.

Aditi Sharma, Pankaj Sharma, Achchhe Lal Vishwakarma, Mrigank Srivastava

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  6. Review
  7. Infective Larvae ofFrontiers in immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aditi SharmaParasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Pankaj SharmaParasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Achchhe Lal VishwakarmaSophisticated Analytical Instrument Facility (SAIF), CSIR-Central Drug Research Institute, Lucknow, India.
Mrigank SrivastavaParasitology Division, CSIR-Central Drug Research Institute, Lucknow, India mrigank_srivastava@cdri.res.in.
Central Drug Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Filarial parasites cause functional impairment of host dendritic cells (DCs). However, the effects of early infection on individual DC subsets are not known. In this study, we infected BALB/c mice with infective stage 3 larvae of the lymphatic filarial parasite Brugia malayi (Bm-L3) and studied the effect on fluorescence-activated cell sorter (FACS)-sorted DC subsets. While myeloid DCs (mDCs) accumulated by day 3 postinfection (p.i.), lymphoid DCs (LDCs) and CD8

Indexed as

AnimalsBrugia malayiCD8-Positive T-LymphocytesCell ProliferationDendritic CellsDown-RegulationFilariasisInterleukin-10Interleukin-12Interleukin-4LarvaLymphocyte ActivationMiceMice, Inbred BALB CProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 2Interleukin-10Interleukin-12Interleukin-4Protein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 2Protein Tyrosine Phosphatase, Non-Receptor Type 6PTEN PhosphohydrolasePtpn1 protein, mousePtpn6 protein, mouseToll-Like ReceptorsTumor Necrosis Factor-alphafilariasisflow cytometrylymphoid dendritic cellsMAP kinasesmyeloid dendritic cellsplasmacytoid dendritic cellsToll-like receptors

Identifiers

PMID27799335
PMCPMC5203645
OpenAlexW2541930147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.