Evidence map›Paper›PMID 27799334›Full record

ArticleInfection and immunity2017

Distinct Effects of Integrins αXβ2 and αMβ2 on Leukocyte Subpopulations during Inflammation and Antimicrobial Responses.

Samir Jawhara, Elzbieta Pluskota, Wei Cao, Edward F Plow, Dmitry A Soloviev

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Functional unfolding of the integrin αX transmembrane helix.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Journal of fungi (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Targeting integrin pathways: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2023
    Review
  11. CSK-mediated signalling by integrins in cancer.Frontiers in cell and developmental biology · 2023
    Review
  12. Review
  13. Conserved and Distinct Elements of Phagocytosis in Human andInternational journal of molecular sciences · 2021
    Review
  14. Article
  15. Frontline Science: The expression of integrin αJournal of leukocyte biology · 2021
    Article
  16. American journal of physiology. Heart and circulatory physiology · 2021
    Review
  17. Review
  18. Review
  19. Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.Mammalian genome : official journal of the International Mammalian Genome Society · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samir JawharaDepartment of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Elzbieta PluskotaDepartment of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Wei CaoDepartment of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Edward F PlowDepartment of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Dmitry A SolovievDepartment of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA solovjd@ccf.org.
Cleveland Clinic Lerner College of Medicine · US

Funding

Structure Basis for Talin-mediated Integrin ActivationP01HL073311 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2004 to 2019
$27.4M
Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
Activation of the beta-3 integrins: Role of the KindlinsR01HL096062 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2009 to 2022
$5.6M
NHLBI NIH HHS P01 HL073311NHLBI NIH HHS P01 HL076491NHLBI NIH HHS R01 HL096062
6 · The paper itself

Abstract

Integrins α

Indexed as

AnimalsAnti-Infective AgentsCandida albicansCandidiasisCell AdhesionEscherichia coliEscherichia coli InfectionsInflammationIntegrin alphaXbeta2Interleukin-10Interleukin-6LeukocytesMacrophage-1 AntigenMiceMice, Inbred C57BLNeutrophilsAnti-Infective AgentsIntegrin alphaXbeta2Interleukin-10Interleukin-6Macrophage-1 AntigenTumor Necrosis Factor-alphaanimal modelsCandida albicanscytokinesEscherichia coliinfection controlinflammationintegrinsmacrophagesmonocytesneutrophils

Identifiers

PMID27799334
PMCPMC5203657
OpenAlexW2542447898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.