Evidence map›Paper›PMID 27799223›Full record

ArticleAntimicrobial agents and chemotherapy2017

Evaluation of MIC Strip Isavuconazole Test for Susceptibility Testing of Wild-Type and Non-Wild-Type Aspergillus fumigatus Isolates.

Maiken Cavling Arendrup, Paul Verweij, Henrik Vedel Nielsen

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Studies in mycology · 2021
    Review
  3. Review
  4. (New) Methods for Detection ofCurrent fungal infection reports · 2019
    Article
  5. Susceptibility Testing of Fungi to Antifungal Drugs.Journal of fungi (Basel, Switzerland) · 2018
    Review
  6. Review
  7. Frontiers in microbiology · 2018
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maiken Cavling ArendrupUnit of Mycology, Statens Serum Institut, Copenhagen, Denmark maca@ssi.dk.
Paul VerweijDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Henrik Vedel NielsenUnit of Mycology, Statens Serum Institut, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the MIC Strip Isavuconazole test against EUCAST E.Def 9.3 by using 40 wild-type and 39 CYP51A mutant Aspergillus fumigatus strains. The strip full inhibition endpoint (FIE) and 80% growth inhibition endpoint were determined by two independent readers, reader 1 (R1) and R2. The essential (within ±0, ±1, and ±2 twofold dilutions) and categorical agreements were best with the FIE (for R1/R2, 42%/41%, 75%/73%, and 90%/89% for essential agreement, and 91.1%/92.4% categorical agreement, with 6.3/8.9% very major errors and 0/1.3% major errors, respectively). The MIC Strip Isavuconazole test with the FIE appears to be useful.

Indexed as

Antifungal AgentsAspergillus fumigatusCytochrome P-450 Enzyme SystemFungal ProteinsMicrobial Sensitivity TestsMutationNitrilesPyridinesTriazolesAntifungal Agentscytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsisavuconazoleNitrilesPyridinesTriazolesantifungal susceptibility testingAspergillus fumigatusCyp51A mutantsEUCASTgradient stripisavuconazoleMICwild type

Identifiers

PMID27799223
PMCPMC5192160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.