Evidence map›Paper›PMID 27799056›Full record

ReviewParticle and fibre toxicology2016

Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms.

Lingling Ou, Bin Song, Huimin Liang, Jia Liu, Xiaoli Feng, Bin Deng, Ting Sun, Longquan Shao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Particle and fibre toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 1 pooled it
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 1 synthesis or guideline pooled it, 785 citations in OpenAlex.

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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lingling OuThe First Affiliated Hospital of Jinan University, Guangzhou, China.
Bin SongNanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Huimin LiangNanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jia LiuNanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xiaoli FengNanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Bin DengThe General Hospital of People's Liberation Army, Beijing, China.
Ting SunThe First Affiliated Hospital of Jinan University, Guangzhou, China.
Longquan ShaoNanfang Hospital, Southern Medical University, Guangzhou, 510515, China. shaolongquan@smu.edu.cn.
Southern Medical University · CNFirst Affiliated Hospital of Jinan University · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to their unique physicochemical properties, graphene-family nanomaterials (GFNs) are widely used in many fields, especially in biomedical applications. Currently, many studies have investigated the biocompatibility and toxicity of GFNs in vivo and in intro. Generally, GFNs may exert different degrees of toxicity in animals or cell models by following with different administration routes and penetrating through physiological barriers, subsequently being distributed in tissues or located in cells, eventually being excreted out of the bodies. This review collects studies on the toxic effects of GFNs in several organs and cell models. We also point out that various factors determine the toxicity of GFNs including the lateral size, surface structure, functionalization, charge, impurities, aggregations, and corona effect ect. In addition, several typical mechanisms underlying GFN toxicity have been revealed, for instance, physical destruction, oxidative stress, DNA damage, inflammatory response, apoptosis, autophagy, and necrosis. In these mechanisms, (toll-like receptors-) TLR-, transforming growth factor β- (TGF-β-) and tumor necrosis factor-alpha (TNF-α) dependent-pathways are involved in the signalling pathway network, and oxidative stress plays a crucial role in these pathways. In this review, we summarize the available information on regulating factors and the mechanisms of GFNs toxicity, and propose some challenges and suggestions for further investigations of GFNs, with the aim of completing the toxicology mechanisms, and providing suggestions to improve the biological safety of GFNs and facilitate their wide application.

Indexed as

AnimalsDrug Administration RoutesGraphiteNanoparticlesTissue DistributionGraphiteFuture prospectsGraphene-family nanomaterialsMechanismsPhysicochemical propertiesToxicityToxicokinetics

Identifiers

PMID27799056
PMCPMC5088662
OpenAlexW2542924420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.