ArticleEuropean radiology2017
Structural brain alterations of Down's syndrome in early childhood evaluation by DTI and volumetric analyses.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pediatric Brain Development in Down Syndrome: A Field in Its Infancy.Journal of the International Neuropsychological Society : JINS · 2018Pooled it
- Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- Enduring differential patterns of neuronal loss and myelination along 6-month pulsatile gonadotropin-releasing hormone therapy in individuals with Down syndrome.Brain communications · 2025Article
- Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome.Journal of neurodevelopmental disorders · 2024Article
- Volumetric differences of thalamic nuclei in children with trisomy 21.The neuroradiology journal · 2023Article
- The mismatch negativity as an index of cognitive abilities in adults with Down syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Comprehensive volumetric phenotyping of the neonatal brain in Down syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Analysis of Heart Rate, Perception of Physical Effort and Performance of Individuals with Down Syndrome Submitted to a Protocol of Virtual Games for Home-Based Telerehabilitation.Healthcare (Basel, Switzerland) · 2023Article
- Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review.Frontiers in neuroscience · 2023Article
- Energy analysis of gait in patients with down syndrome.Heliyon · 2022Article
- Structural Connectivity in Down Syndrome and Alzheimer's Disease.Frontiers in neuroscience · 2022Review
- Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans.Frontiers in cell and developmental biology · 2022Review
- Brain structural alterations in young girls with Rett syndrome: A voxel-based morphometry and tract-based spatial statistics study.Frontiers in neuroinformatics · 2022Article
- Left lateralization of neonatal caudate microstructure affects emerging language development at 24 months.The European journal of neuroscience · 2021Article
- Microstructural white matter abnormalities in hypothyroidism evaluation with diffusion tensor imaging tract-based spatial statistical analysis.La Radiologia medica · 2021Article
- Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry.Scientific reports · 2020Article
- Review
- Structural Magnetic Resonance Imaging-Based Brain Morphology Study in Infants and Toddlers With Down Syndrome: The Effect of Comorbidities.Pediatric neurology · 2019Article
- Reduction of bias in the evaluation of fractional anisotropy and mean diffusivity in magnetic resonance diffusion tensor imaging using region-of-interest methodology.Scientific reports · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo provide an initial assessment of white matter (WM) integrity with diffusion tensor imaging (DTI) and the accompanying volumetric changes in WM and grey matter (GM) through volumetric analyses of young children with Down's syndrome (DS).
methodsTen children with DS and eight healthy control subjects were included in the study. Tract-based spatial statistics (TBSS) were used in the DTI study for whole-brain voxelwise analysis of fractional anisotropy (FA) and mean diffusivity (MD) of WM. Volumetric analyses were performed with an automated segmentation method to obtain regional measurements of cortical volumes.
resultsChildren with DS showed significantly reduced FA in association tracts of the fronto-temporo-occipital regions as well as the corpus callosum (CC) and anterior limb of the internal capsule (p < 0.05). Volumetric reductions included total cortical GM, cerebellar GM and WM volume, basal ganglia, thalamus, brainstem and CC in DS compared with controls (p < 0.05).
conclusionThese preliminary results suggest that DTI and volumetric analyses may reflect the earliest complementary changes of the neurodevelopmental delay in children with DS and can serve as surrogate biomarkers of the specific elements of WM and GM integrity for cognitive development. KEY POINTS: • DS is the most common genetic cause of intellectual disability. • WM and GM structural alterations represent the neurological features of DS. • DTI may identify the earliest aging process changes. • DTI-volumetric analyses can serve as surrogate biomarkers of neurodevelopment in DS.
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