ArticlePloS one2016
Monopolar Detection Thresholds Predict Spatial Selectivity of Neural Excitation in Cochlear Implants: Implications for Speech Recognition.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03870217 (Comparing Site-selection Strategies for Improving Speech Recognition Outcomes), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Site-selection Strategies for Improving Speech Recognition Outcomes
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Cochlear implant re-mapping informed by measures of viability of the electrode-neural interface: a systematic review with meta-analysis.Scientific reports · 2025Pooled it
- Within-electrode temporal envelope processing predicts multi-channel speech outcomes across cochlear implant pulse rates.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of Spiral Ganglion Lesions by Electrophysiological Measures.Brain sciences · 2026Article
- Electrode deactivation in cochlear implant users: impact on speech perception and objective measures.CoDAS · 2026Article
- Cochlear Implant Electrode Placement and Music Perception.JAMA otolaryngology-- head & neck surgery · 2025Article
- The relationship between channel interaction, electrode placement, and speech perception in adult cochlear implant users.The Journal of the Acoustical Society of America · 2024Article
- Article
- Combining Place and Rate of Stimulation Improves Frequency Discrimination in Cochlear Implant Users.Hearing research · 2022Article
- Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Auditory performance of post-lingually deafened adult cochlear implant recipients using electrode deactivation based on postoperative cone beam CT images.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Polarity Sensitivity of Human Auditory Nerve Fibers Based on Pulse Shape, Cochlear Implant Stimulation Strategy and Array.Frontiers in neuroscience · 2021Article
- Using Spectral Blurring to Assess Effects of Channel Interaction on Speech-in-Noise Perception with Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Forward masking patterns by low and high-rate stimulation in cochlear implant users: Differences in masking effectiveness and spread of neural excitation.Hearing research · 2020Article
- Effect of pulse phase duration on forward masking and spread of excitation in cochlear implant listeners.PloS one · 2020Observational
- Article
- Longitudinal effect of deactivating stimulation sites based on low-rate thresholds on speech recognition in cochlear implant users.International journal of audiology · 2019Article
- A Site-Selection Strategy Based on Polarity Sensitivity for Cochlear Implants: Effects on Spectro-Temporal Resolution and Speech Perception.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Pulse-rate discrimination deficit in cochlear implant users: is the upper limit of pitch peripheral or central?Hearing research · 2019Article
- Deactivating cochlear implant electrodes to improve speech perception: A computational approach.Hearing research · 2018Article
- Temporal Modulation Detection Depends on Sharpness of Spatial Tuning.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The objectives of the study were to (1) investigate the potential of using monopolar psychophysical detection thresholds for estimating spatial selectivity of neural excitation with cochlear implants and to (2) examine the effect of site removal on speech recognition based on the threshold measure. Detection thresholds were measured in Cochlear Nucleus® device users using monopolar stimulation for pulse trains that were of (a) low rate and long duration, (b) high rate and short duration, and (c) high rate and long duration. Spatial selectivity of neural excitation was estimated by a forward-masking paradigm, where the probe threshold elevation in the presence of a forward masker was measured as a function of masker-probe separation. The strength of the correlation between the monopolar thresholds and the slopes of the masking patterns systematically reduced as neural response of the threshold stimulus involved interpulse interactions (refractoriness and sub-threshold adaptation), and spike-rate adaptation. Detection threshold for the low-rate stimulus most strongly correlated with the spread of forward masking patterns and the correlation reduced for long and high rate pulse trains. The low-rate thresholds were then measured for all electrodes across the array for each subject. Subsequently, speech recognition was tested with experimental maps that deactivated five stimulation sites with the highest thresholds and five randomly chosen ones. Performance with deactivating the high-threshold sites was better than performance with the subjects' clinical map used every day with all electrodes active, in both quiet and background noise. Performance with random deactivation was on average poorer than that with the clinical map but the difference was not significant. These results suggested that the monopolar low-rate thresholds are related to the spatial neural excitation patterns in cochlear implant users and can be used to select sites for more optimal speech recognition performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.