ArticlePloS one2016
Vibrio vulnificus Type 6 Secretion System 1 Contains Anti-Bacterial Properties.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Emergence, climate-driven expansion, and diversification of a EuropeanEmerging microbes & infections · 2026Article
- Phylogeny-aware comparative genomics ofmBio · 2026Article
- Comparative Transcriptomic Analysis Underlies the Differential Virulence ofInternational journal of molecular sciences · 2025Article
- Epidemiological and genetic charateristics of Vibrio vulnificus from diverse sources in China during 2012-2023.Communications biology · 2025Article
- Clonal Dynamics, Virulence Genes, Antimicrobial Resistance, and Early Diagnostic Indicators of Bloodstream Infections ofInfection and drug resistance · 2025Article
- Genomic Insight into Zoonotic and EnvironmentalMicroorganisms · 2024Article
- The coral pathogen Vibrio coralliilyticus uses a T6SS to secrete a group of novel anti-eukaryotic effectors that contribute to virulence.PLoS biology · 2024Article
- The RIX domain defines a class of polymorphic T6SS effectors and secreted adaptors.Nature communications · 2023Article
- PandemicLife science alliance · 2023Article
- Type VI Secretion Systems: Environmental and Intra-host Competition of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- Prevalence and diversity of type VI secretion systems in a model beneficial symbiosis.Frontiers in microbiology · 2022Article
- Effects of intestinal microbiota on physiological metabolism and pathogenicity ofFrontiers in microbiology · 2022Review
- Activation of the Type VI Secretion System in the Squid SymbiontJournal of bacteriology · 2021Article
- Accumulation of dead cells from contact killing facilitates coexistence in bacterial biofilms.Journal of the Royal Society, Interface · 2020Article
- Article
- Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species.Environmental microbiology · 2019Article
- The Antibacterial and Anti-Eukaryotic Type VI Secretion System MIX-Effector Repertoire inMarine drugs · 2018Article
- Complete Genome Sequence ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio vulnificus is a bacterium responsible for severe gastroenteritis, sepsis and wound infections. Gastroenteritis and sepsis are commonly associated with the consumption of raw oysters, whereas wound infection is often associated with the handling of contaminated fish. Although classical virulence factors of this emerging pathogen are well characterised, there remains a paucity of knowledge regarding the general biology of this species. To investigate the presence of previously unreported virulence factors, we applied whole genome sequencing to a panel of ten V. vulnificus strains with varying virulence potentials. This identified two novel type 6 secretion systems (T6SSs), systems that are known to have a role in bacterial virulence and population dynamics. By utilising a range of molecular techniques and assays we have demonstrated the functionality of one of these T6SSs. Furthermore, we have shown that this system is subject to thermoregulation and is negatively regulated by increasing salinity concentrations. This secretion system was also shown to be involved in the killing of V. vulnificus strains that did not possess this system and a model is proposed as to how this interaction may contribute to population dynamics within V. vulnificus strains. In addition to this intra-species killing, this system also contributes to the killing of inter bacterial species and may have a role in the general composition of Vibrio species in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.