ArticleNature genetics2016
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Open access · hybridAbstract read
In one paragraph
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 10 pooled it
77.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 10 syntheses or guidelines pooled it, 375 citations in OpenAlex.
- Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.Nature genetics · 2025Pooled it
- Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis.BMC psychiatry · 2024Pooled it
- Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies.BMC medicine · 2023Pooled it
- The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.Nature genetics · 2023Pooled it
- Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.Communications biology · 2020Pooled it
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.Nature genetics · 2019Pooled it
- A scientometric review of genome-wide association studies.Communications biology · 2019Pooled it
- Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.Nature genetics · 2018Pooled it
- Pooled it
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Genetic links between female reproductive milestones and major depressive disorder: evidence from a common genetic factor model.Archives of women's mental health · 2026Article
- Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling.medRxiv : the preprint server for health sciences · 2026Article
- Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans.Nature ecology & evolution · 2026Article
- SNPannotator: automated functional annotation of genetic variants and linked proxies.Bioinformatics (Oxford, England) · 2026Article
- Mendelian randomization in ovarian research: applications in PCOS, ovarian aging, and assisted reproductive technology.Journal of ovarian research · 2026Review
- Article
- Exploring the genetic overlap between substance use disorder and educational attainment.Addiction (Abingdon, England) · 2026Article
- A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
255 authors at 20 institutions in 21 countries.
Nicola BarbanDepartment of Sociology and Nuffield College, University of Oxford, Oxford, UK.ORCID 0000-0002-4362-4652
Rick JansenDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.ORCID 0000-0002-3333-6737
Ronald de VlamingDepartment of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.
Ahmad VaezDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-9048-3795
Jornt J MandemakersSociology of Consumption and Households, Wageningen University Research, Wageningen, the Netherlands.
Felix C TropfDepartment of Sociology and Nuffield College, University of Oxford, Oxford, UK.
Xia ShenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
James F WilsonMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Daniel I ChasmanBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Vinicius TraganteDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
Sander W van der LaanLaboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
John R B PerryMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Augustine KongSchool of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
BIOS Consortium
Tarunveer S AhluwaliaNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Laura Yerges-ArmstrongDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Gil AtzmonDepartment of Medicine, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Kirsi AuroDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Kristin AyersInstitute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Andrew BakshiQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Danny Ben-AvrahamDepartment of Genetics, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Aviv BergmanDepartments of Systems and Computational Biology, of Pathology and of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and of Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
Lawrence F BielakDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Gyda BjornsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Marc Jan BonderDepartment of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Linda BroerDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Minh BuiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Caterina BarbieriDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Alana CavadinoPopulation, Policy and Practice, UCL Institute of Child Health, London, UK.
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Maria Pina ConcasInstitute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.
Heather J CordellInstitute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Peter EibichHealth Economics Research Centre, University of Oxford, Oxford, UK.
Nicholas Eriksson23andMe, Inc., Mountain View, California, USA.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Joel ErikssonCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Fahimeh FalahiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Mark Alan FontanaCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Lude FrankeDepartment of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ilaria GandinDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Audrey J GaskinsDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Erica P GundersonCardiovascular and Metabolic Conditions Section, Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Chunyan HeDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Hongyan HuangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Peter K JoshiCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Stefan KiechlDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Annette KifleyCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Alexander KluttigInstitute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Vasiliki LagouDepartment of Neurosciences, KU Leuven, Leuven, Belgium.
Cecile LecoeurUniversity of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Jari LahtiInstitute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.
Tian LiuCenter for Lifespan Psychology, Max Planck Institute for Human Development and Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Enes MakalicCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Crysovalanto MamasoulaInstitute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Lindsay MattesonMinnesota Center for Twin and Family Research, Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Hamdi MbarekDepartment of Biological Psychology, VU University, Amsterdam, the Netherlands.
Patrick F McArdleDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
George McMahonSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
S Fleur W MeddensErasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Mike MillerDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Stacey A MissmerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Claire MonnereauDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ronny MyhreDepartment of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Teresa NutileInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Ioanna Panagiota KalafatiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Eleonora PorcuIstituto di Ricerca Genetica e Biomedica, CMR, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
Inga ProkopenkoDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.
Kumar B RajanRush University Medical Center, Chicago, Illinois, USA.
Janet Rich-EdwardsDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Cornelius A RietveldDepartment of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.
Antonietta RobinoInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Lynda M RoseBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Rico RueediDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Kathleen A RyanDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yasaman SabaInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.
Daniel SchmidtCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Lisette StolkDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Elizabeth StreetenDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Anke TönjesDepartment of Medicine, University of Leipzig, Leipzig, Germany.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Sheila UliviInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Juho WedenojaDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Juergen WellmannInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Peter WilleitDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Jie YaoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Loic YengoUniversity of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Jing Hua ZhaoMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Daria V ZhernakovaDepartment of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Najaf AminDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Howard AndrewsData Coordinating Center, New York State Psychiatric Institute, New York, New York, USA.
Beverley BalkauUniversity of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Nir BarzilaiDepartment of Medicine, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Sven BergmannDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, the Netherlands.
Julie E BuringBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Stefania CappellaniInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Marina CiulloInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Simon R CoxCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, CMR, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
George Davey-SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Eco J C de GeusDepartment of Biological Psychology, VU University, Amsterdam, the Netherlands.
Johan G ErikssonFolkhälsan Research Centre, Helsinki, Finland.
Denis A EvansRush University Medical Center, Chicago, Illinois, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Cinzia Felicita SalaDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Philippe FroguelUniversity of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Paolo GaspariniDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Giorgia GirottoDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Hans-Jörgen GrabeDepartment of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
Karin Halina GreiserDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Patrick J F GroenenErasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
Hugoline G de HaanDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Johannes HaertingInstitute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Andrew C HeathGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kauko HeikkiläInstitute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Elizabeth G HollidaySchool of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
John HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Elina HyppönenPopulation, Policy and Practice, UCL Institute of Child Health, London, UK.
Bo JacobssonDepartment of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Vincent W V JaddoeDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Magnus JohannessonDepartment of Economics, Stockholm School of Economics, Stockholm, Sweden.
Astanand JugessurDepartment of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Mika KähönenDepartment of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
Eero KajantieDiabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Bernard KeavneyInstitute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Päivikki KoponenHealth Monitoring Unit, National Institute for Health and Welfare, Helsinki, Finland.
Peter KovacsIFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
Zoltan KutalikSwiss Institute of Bioinformatics, Lausanne, Switzerland.
Martina La BiancaInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Genevieve LachanceDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Sandra LaiIstituto di Ricerca Genetica e Biomedica, CMR, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
David C LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
LifeLines Cohort Study
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Yongmei LiuDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Robert LubenStrangeways Research Laboratory, University of Cambridge, Cambridge, UK.
Michael LuchtDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Riitta LuotoUKK Institute for Health Promotion,Tampere, Finland.
Per MagnusDepartment of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nicholas G MartinPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Ruth McQuillanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Dan MellströmCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Michela TragliaDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Paul MitchellCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Grant W MontgomeryGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Dennis Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Ellen A NohrResearch Unit for Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Claes OhlssonCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jørn OlsenDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
Ken K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Lavinia PaternosterMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Alison PattieDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Brenda W J H PenninxDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Markus PerolaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Patricia A PeyserDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Mario PirastuInstitute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.
Ozren PolasekDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Chris PowerPopulation, Policy and Practice, UCL Institute of Child Health, London, UK.
Jaakko KaprioDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Leslie J RaffelMedical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Katri RäikkönenInstitute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Paul M RidkerBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Susan M RingMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Kathryn RollInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Daniela RuggieroInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Dan RujescuDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Veikko SalomaaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
David SchlessingerLaboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Nicole SchupfDepartments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, New York, USA.
Johannes SmitDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Rossella SoriceInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Doris StöcklDepartments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, New York, USA.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Michael StumvollDepartment of Medicine, University of Leipzig, Leipzig, Germany.
Morris A SwertzDepartment of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
A Roy ThurikDepartment of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Joyce Y Tung23andMe, Inc., Mountain View, California, USA.
André G UitterlindenDepartment of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.
Simona VaccargiuInstitute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.
Jorma ViikariDepartment of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.
Veronique VitartMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Peter VollenweiderDepartment of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Dragana VuckovicDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Johannes WaageCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Gert G WagnerGerman Socio-Economic Panel Study (SOEP), Max Planck Institute for Human Development and Berlin University of Technology (TUB), Berlin, Germany.
Jie Jin WangCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Gonneke WillemsenDepartment of Biological Psychology, VU University, Amsterdam, the Netherlands.
Johann WilleitDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Alan F WrightMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Krina T ZondervanGenetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
James J LeeDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Daniel J BenjaminCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
David CesariniDepartment of Economics, New York University, New York, New York, USA.
Philipp D KoellingerDepartment of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.
Marcel den HoedDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Melinda C MillsDepartment of Sociology and Nuffield College, University of Oxford, Oxford, UK.
Brigham and Women's Hospital · USUniversity of Helsinki · FIUniversity Medical Center Groningen · NLUniversity of Minnesota · USCentre National de la Recherche Scientifique · FRHarvard University · USThe University of Melbourne · AUUniversity of Maryland, Baltimore · USdeCODE Genetics (Iceland) · ISNorwegian Institute of Public Health · NOQIMR Berghofer Medical Research Institute · AUUniversity of Cambridge · GBUniversity of Copenhagen · DKAlbert Einstein College of Medicine · USInnsbruck Medical University · ATUniversity of Michigan · USErasmus MC · NLFinnish Institute for Health and Welfare · FIQueen Mary University of London · GBUniversity of Bristol · GB
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MUnderstanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related DementiasP01AG005842 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI JOSEPH J DOYLE · 1986 to 2026
$56.5MNBER Center for Aging and Health Research-Post COVID-19 Experiences Among Adults with ADRDP30AG012810 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI DAVID M CUTLER · 1999 to 2026
$24.6MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8MNBER Training Program in Aging and Health EconomicsT32AG000186 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI CUTLER, DAVID M, FINKELSTEIN, AMY N. · 1989 to 2024
$9.6MGenes Associated With Ovarian Development and Premature Ovarian Failure - testZIAAG000647 · NIA · NATIONAL INSTITUTE ON AGING · PI SCHLESSINGER, DAVID · 2009 to 2017
$6.2MAging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7MGenome-Wide Analyses of Health and Well-Being PhenotypesR01AG042568 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2015 to 2021
$2.8MNonlinear Models of Cognition Preceding AD in a Biracial Population SampleR01AG051635 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2016 to 2020
$1.5MGenetic analysis of AGES-Reykjavik Study and the Health ABCZIAAG006000 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA · 2009 to 2017
$1.3MBritish Heart Foundation RG/15/12/31616European Research Council 615603European Research Council 647648HSRD VA SDR 10-012Intramural NIH HHS Z99 AG999999Medical Research Council G1001799Medical Research Council G9815508Medical Research Council MC_PC_U127561128Medical Research Council MC_UU_12013/3Medical Research Council MR/J012165/1Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIA NIH HHS P01 AG005842NIA NIH HHS P30 AG012810NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG042568NIA NIH HHS R01 AG051635NIA NIH HHS T32 AG000186NIA NIH HHS U01 AG016976Wellcome Trust 202802/Z/16/Z
Abstract
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Indexed as
Birth OrderGenome-Wide Association StudyQuantitative Trait LociFemaleFertilityHumansMaternal AgeParityPhenotypePolymorphism, Single NucleotidePregnancyReproductionReproductive Behavior
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