ArticleNature immunology2016
Protective neutralizing influenza antibody response in the absence of T follicular helper cells.
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In one paragraph
Article in Nature immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 141 citations in OpenAlex.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells.Science advances · 2026Article
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Germinal center-independent memory B cells provide rapid protection from lethal influenza challenges.bioRxiv : the preprint server for biology · 2026Article
- A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle-based mRNA vaccines.Science advances · 2026Article
- Post-vaccination expansion of extrafollicular Th10 and regulatory Tfr cells distinguishes strong from weak influenza vaccine responses in older adults.medRxiv : the preprint server for health sciences · 2026Article
- Extrafollicular and other non-germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective.Immunological reviews · 2025Review
- Coordinated Regulation of Extrafollicular B Cell Responses by IL-12 and IFNγ.Immunological reviews · 2025Review
- Systems immunology analysis of human immune organoids identifies host-specific correlates of protection to different influenza vaccines.Cell stem cell · 2025Article
- Co-Delivery of Multiple Toll-Like Receptor Agonists and Avian Influenza Hemagglutinin on Protein Nanoparticles Enhances Vaccine Immunogenicity and Efficacy.Advanced healthcare materials · 2025Article
- mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.Journal of virology · 2025Article
- Atopic skin inflammation promotes systemic anaphylactic responses via IL-13 signaling in conventional dendritic cells.Research square · 2025Article
- Article
- Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics.Frontiers in immunology · 2025Review
- Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset.Frontiers in immunology · 2025Review
- Human axillary lymph node T follicular helper (Tfh) and Precursor-Tfh cells exhibit functional flexibility following seasonal influenza vaccination.Clinical & translational immunology · 2025Article
- Lipid nanoparticles as adjuvant of norovirus VLP vaccine augment cellular and humoral immune responses in a TLR9- and type I IFN-dependent pathway.Journal of virology · 2024Article
- Article
- An Integrated Signaling Threshold Initiates IgG Response toward Virus-like Immunogens.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 2 countries.
Kosuke MiyauchiLaboratory for Cytokine Regulation, Research Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Akiko Sugimoto-IshigeDrug Discovery Antibody Platform Unit, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Yasuyo HaradaDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Noda, Japan.
Yu AdachiDepartment of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
Yoshiko UsamiLaboratory for Cytokine Regulation, Research Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Tomohiro KajiDrug Discovery Antibody Platform Unit, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Kentaro InoueLaboratory for Integrated Cellular Systems, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Hideki HasegawaDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Takashi WatanabeLaboratory for Integrative Genomics, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Atsushi HijikataDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Japan.
Satoshi FukuyamaDivision of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Tadashi MaemuraDivision of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Mariko Okada-HatakeyamaLaboratory for Integrated Cellular Systems, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Osamu OharaLaboratory for Integrative Genomics, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Yoshihiro KawaokaDivision of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Yoshimasa TakahashiDepartment of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
Toshitada TakemoriDrug Discovery Antibody Platform Unit, IMS, RIKEN Yokohama Institute, Yokohama, Japan.
Masato KuboLaboratory for Cytokine Regulation, Research Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
RIKEN Center for Integrative Medical Sciences · JPNational Institute of Infectious Diseases · JPDaiichi-Sankyo (Japan) · JPNagahama Institute of Bio-Science and Technology · JPTokyo University of Science · JPUniversity of Wisconsin–Madison · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus infection induces the development of T follicular helper (T
Indexed as
AnimalsAntibodies, NeutralizingAntibodies, ViralCells, CulturedGerminal CenterHumansImmunoglobulin GInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza VaccinesInterferon-gammaInterleukin-21InterleukinsMiceMice, Inbred C57BLAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GInfluenza VaccinesInterferon-gammaInterleukin-21Interleukins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.