Evidence map›Paper›PMID 27798602›Full record

ArticleNature2016

S-2-hydroxyglutarate regulates CD8

Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 276 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
276citing papers in PubMed, 2 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

276 citing papers in PubMed, 2 syntheses or guidelines pooled it, 418 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Targeting PKM2 Enhances the Anti-Tumor Function of CD8International journal of molecular sciences · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Jump-starting the T cell response in established tumors.bioRxiv : the preprint server for biology · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

216 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Petros A TyrakisDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Asis PalazonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
David MaciasDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Kian L LeeCancer Science Institute of Singapore, National University of Singapore, Singapore.
Anthony T PhanMolecular Biology Section, UC San Diego, La Jolla, California, USA.
Pedro VeliçaDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Jia YouCancer Science Institute of Singapore, National University of Singapore, Singapore.
Grace S ChiaCancer Science Institute of Singapore, National University of Singapore, Singapore.
Jingwei SimDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Andrew DoedensMolecular Biology Section, UC San Diego, La Jolla, California, USA.
Alice AbelanetDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Colin E EvansDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
John R GriffithsCancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK.
Lorenz PoellingerCancer Science Institute of Singapore, National University of Singapore, Singapore.
Ananda W GoldrathMolecular Biology Section, UC San Diego, La Jolla, California, USA.
Randall S JohnsonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
University of Cambridge · GBNational University Cancer Institute, Singapore · SGUniversity of California, San Diego · USCancer Research UK · GBKarolinska Institutet · SENational University of Singapore · SG

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Regulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4M
Metabolic Regulation of T cell ImmunityR01AI096852 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2012 to 2015
$1.5M
Cancer Research UK 11562NIAID NIH HHS R01 AI072117NIAID NIH HHS R01 AI096852NIGMS NIH HHS T32 GM007240NIH HHS A1072117NIH HHS A1096852Wellcome Trust 092738Wellcome Trust WT092738MA
6 · The paper itself

Abstract

R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both metabolite enantiomers, R- and S-2-hydroxyglutarate, are detectible in healthy individuals, yet their physiological function remains elusive. Here we show that 2-hydroxyglutarate accumulates in mouse CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationDioxygenasesDNADNA MethylationGlutaratesHistonesHomeostasisHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKetoglutaric AcidsLymphocyte ActivationLysineMiceOxygenalpha-hydroxyglutarateDioxygenasesDNAGlutaratesHif1a protein, mouseHistonesHypoxia-Inducible Factor 1, alpha SubunitKetoglutaric AcidsLysineOxygenReceptors, Antigen, T-CellVHL protein, mouseVon Hippel-Lindau Tumor Suppressor Protein

Identifiers

PMID27798602
PMCPMC5149074
OpenAlexW2537440061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.