ArticlePhysiological reports2016
Lack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 7 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 7 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Mental Roots of Performance: A Preliminary Meta-Analysis of Cognitive Genes and Athlete Status.Molecular neurobiology · 2025Pooled it
- Candidate gene polymorphisms and power athlete status: a meta-analytical approach.Journal of physiology and biochemistry · 2025Pooled it
- Prediction of success in sports based on assumed individual genetic predisposition: lack of association with the C > T variant in the ACTN3 gene.Journal of physiological anthropology · 2025Pooled it
- Association between theFrontiers in physiology · 2025Pooled it
- Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status.European journal of applied physiology · 2024Pooled it
- Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.PloS one · 2021Pooled it
- Association of PPARGC1A Gly428Ser (rs8192678) polymorphism with potential for athletic ability and sports performance: A meta-analysis.PloS one · 2019Pooled it
- Reevaluating the total genotype score: a practical perspective from applied sport science.Journal of applied genetics · 2025Article
- Interactions Between Monocarboxylate TransporterGenes · 2025Article
- Genomic information in the decision-making process for the training of a high-performance brazilian swimmer: a case report.Frontiers in genetics · 2025Article
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- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
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- TheBiology of sport · 2021Article
- Total Genotype Score Modelling of Polygenic Endurance-Power Profiles in Lithuanian Elite Athletes.Genes · 2021Article
- Whole Genome Interpretation for a Family of Five.Frontiers in genetics · 2021Article
- Article
- Association of Elite Sports Status with Gene Variants of Peroxisome Proliferator Activated Receptors and Their Transcriptional Coactivator.International journal of molecular sciences · 2019Review
- Meta-analyses of the association between theBiology of sport · 2019Article
- The magnitude of Yo-Yo test improvements following an aerobic training intervention are associated with total genotype score.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to examine a polygenic profile related to endurance performance, based on current knowledge, in the Japanese population. We analyzed 21 genetic polymorphisms that have been reported to be associated with endurance performance and its related phenotypes in 175 endurance runners (60 international-, 94 national-, and 21 regional-level) and 649 controls in the Japanese population. Then, we calculated the total genotype score (TGS) (maximum value of 100 for the theoretically optimum polygenic score) for endurance performance. There was no association between the TGS and endurance athlete status (Control: 49.0 ± 7.6, Regional: 47.3 ± 7.6, National: 49.1 ± 5.7, and International: 48.2 ± 7.0, P = 0.626). These results suggested that TGSs based on the 21 previously published endurance performance-associated polymorphisms do not influence endurance running performance in the Japanese population. Nevertheless, some marginal tendencies have to be noted: the frequencies of the ACTN3 R577X rs1815739 RR+RX genotype and the GNB3 rs5443 CC+CT genotype were higher in international athletes than in controls (85% vs. 73.6%, P = 0.042 and 90% vs. 76%, P = 0.007, respectively), but not significantly different after Bonferroni correction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.