Evidence map›Paper›PMID 27798329›Full record

Trial reportThe Journal of nutrition2016

A Whole-Grain Diet Reduces Cardiovascular Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial.

John P Kirwan, Steven K Malin, Amanda R Scelsi, Emily L Kullman, Sankar D Navaneethan, Mangesh R Pagadala, Jacob M Haus, Julianne Filion, Jean-Philippe Godin, Sunil Kochhar and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01411540 (Effects of Diet on Body Composition), which is not on this map. Cited by 60 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 11 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01411540 nacompletednot on this map

Effects of Diet on Body Composition

TypeinterventionalSponsorThe Cleveland ClinicRan2010 to 2014Enrolled35ConditionsOverweight, Obesity, Pre-diabeticArmsWhole grains
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 11 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

John P KirwanDepartment of Pathobiology, Lerner Research Institute, kirwanj@ccf.org.ORCID http://orcid.org/0000-0001-7321-9917
Steven K MalinDepartment of Pathobiology, Lerner Research Institute.
Amanda R ScelsiDepartment of Pathobiology, Lerner Research Institute.
Emily L KullmanDepartment of Pathobiology, Lerner Research Institute.
Sankar D NavaneethanDepartment of Nephrology and Hypertension, Glickman Urological and Kidney Institute, and.
Mangesh R PagadalaDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Jacob M HausDepartment of Pathobiology, Lerner Research Institute.
Julianne FilionDepartment of Pathobiology, Lerner Research Institute.
Jean-Philippe GodinAnalytical Sciences Department, Nestlé Research Center, Lausanne, Switzerland; and.
Sunil KochharAnalytical Sciences Department, Nestlé Research Center, Lausanne, Switzerland; and.
Alastair B RossAnalytical Sciences Department, Nestlé Research Center, Lausanne, Switzerland; and.
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USNestlé (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased dietary whole-grain intake may protect against cardiovascular disease (CVD).

objectiveThe objective was to evaluate the efficacy of whole grains compared with refined grains on body composition, hypertension, and related mediators of CVD in overweight and obese adults.

methodsWe conducted a double-blind, randomized, controlled crossover trial in 40 overweight or obese men and women aged <50 y with no known history of CVD. Complete whole-grain and refined-grain diets were provided for two 8-wk periods, with a 10-wk washout between diets. Macronutrient composition was matched, except for the inclusion of either whole grains or refined grains (50 g/1000 kcal in each diet). Measurements included blood pressure, body composition, blood lipids and adiponectin, and markers of inflammation and glycemia.

resultsThirty-three participants (6 men and 27 women) completed the trial [mean ± SD age: 39 ± 7 y; mean ± SD body mass index (in kg/m

conclusionsThe improvement in diastolic blood pressure was >3-fold greater in overweight and obese adults when they consumed a whole-grain compared with a refined-grain diet. Because diastolic blood pressure predicts mortality in adults aged <50 y, increased whole-grain intake may provide a functional approach to control hypertension. This may benefit patients at risk of vascular-related morbidity and mortality. This trial was registered at clinicaltrials.gov as NCT01411540.

Indexed as

DietOverweightWhole GrainsAdultBlood GlucoseBlood PressureBody CompositionCardiovascular DiseasesDouble-Blind MethodFemaleHumansInsulin ResistanceLipidsMaleMiddle AgedRisk FactorsBlood GlucoseLipidsblood pressurecardiovascular diseasedietobesitywhole grain

Identifiers

PMID27798329
PMCPMC5086786
OpenAlexW2531984840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.