ArticleProceedings. Biological sciences2016
Spatial evolutionary epidemiology of spreading epidemics.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Host dietary niche and site location on the river continuum shape trematode (International journal for parasitology. Parasites and wildlife · 2025Article
- Quantitative Resistance Deployment Can Strengthen Epidemics in Perennial Plants by Selecting Maladapted Pathogen Strains.Evolutionary applications · 2025Article
- Multiscale selection in spatially structured populations.Proceedings. Biological sciences · 2024Article
- Epidemic spreading under mutually independent intra- and inter-host pathogen evolution.Nature communications · 2022Article
- Ecological and evolutionary dynamics of multi-strain RNA viruses.Nature ecology & evolution · 2022Review
- Evolution of class-structured populations in periodic environments.Evolution; international journal of organic evolution · 2022Article
- The three Ts of virulence evolution during zoonotic emergence.Proceedings. Biological sciences · 2021Review
- Evolution of human respiratory virus epidemics.F1000Research · 2021Article
- Evolution of Human Respiratory Virus Epidemics.medRxiv : the preprint server for health sciences · 2020Article
- Interplay between competitive and cooperative interactions in a three-player pathogen system.Royal Society open science · 2020Article
- Infection in patchy populations: Contrasting pathogen invasion success and dispersal at varying times since host colonization.Evolution letters · 2019Article
- Host contact dynamics shapes richness and dominance of pathogen strains.PLoS computational biology · 2019Article
- Review
- Pathogen evolution in finite populations: slow and steady spreads the best.Journal of the Royal Society, Interface · 2018Article
- Assessing the durability and efficiency of landscape-based strategies to deploy plant resistance to pathogens.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most spatial models of host-parasite interactions either neglect the possibility of pathogen evolution or consider that this process is slow enough for epidemiological dynamics to reach an equilibrium on a fast timescale. Here, we propose a novel approach to jointly model the epidemiological and evolutionary dynamics of spatially structured host and pathogen populations. Starting from a multi-strain epidemiological model, we use a combination of spatial moment equations and quantitative genetics to analyse the dynamics of mean transmission and virulence in the population. A key insight of our approach is that, even in the absence of long-term evolutionary consequences, spatial structure can affect the short-term evolution of pathogens because of the build-up of spatial differentiation in mean virulence. We show that spatial differentiation is driven by a balance between epidemiological and genetic effects, and this quantity is related to the effect of kin competition discussed in previous studies of parasite evolution in spatially structured host populations. Our analysis can be used to understand and predict the transient evolutionary dynamics of pathogens and the emergence of spatial patterns of phenotypic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.