ArticleJournal of the Royal Society, Interface2016
Steady dynein forces induce flutter instability and propagating waves in mathematical models of flagella.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Quantification of flagellar gait changes with combined shape mode analysis and swimming simulations.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Effect of fluid elasticity on the emergence of oscillations in an active elastic filament.Journal of the Royal Society, Interface · 2024Article
- The reaction-diffusion basis of animated patterns in eukaryotic flagella.Nature communications · 2023Article
- Article
- Generation of ciliary beating by steady dynein activity: the effects of inter-filament coupling in multi-filament models.Journal of the Royal Society, Interface · 2022Article
- Article
- Ciliary beating patterns map onto a low-dimensional behavioural space.Nature physics · 2022Article
- Active beating modes of two clamped filaments driven by molecular motors.Journal of the Royal Society, Interface · 2022Article
- The many modes of flagellar and ciliary beating: Insights from a physical analysis.Cytoskeleton (Hoboken, N.J.) · 2021Review
- Swirling Instability of the Microtubule Cytoskeleton.Physical review letters · 2021Article
- Collective dynamics of sperm cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Internal friction controls active ciliary oscillations near the instability threshold.Science advances · 2020Article
- Buckling instabilities and spatio-temporal dynamics of active elastic filaments.Journal of the Royal Society, Interface · 2020Article
- Multiscale mechanics of mucociliary clearance in the lung.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- On the unity and diversity of cilia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Cilia oscillations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Asymmetries in the cilia ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- How Does Cilium Length Affect Beating?Biophysical journal · 2019Article
- Instability-driven oscillations of elastic microfilaments.Journal of the Royal Society, Interface · 2018Article
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Authors and funding
2 authors.
Funding
Abstract
Cilia and flagella are highly conserved organelles that beat rhythmically with propulsive, oscillatory waveforms. The mechanism that produces these autonomous oscillations remains a mystery. It is widely believed that dynein activity must be dynamically regulated (switched on and off, or modulated) on opposite sides of the axoneme to produce oscillations. A variety of regulation mechanisms have been proposed based on feedback from mechanical deformation to dynein force. In this paper, we show that a much simpler interaction between dynein and the passive components of the axoneme can produce coordinated, propulsive oscillations. Steady, distributed axial forces, acting in opposite directions on coupled beams in viscous fluid, lead to dynamic structural instability and oscillatory, wave-like motion. This 'flutter' instability is a dynamic analogue to the well-known static instability, buckling. Flutter also occurs in slender beams subjected to tangential axial loads, in aircraft wings exposed to steady air flow and in flexible pipes conveying fluid. By analysis of the flagellar equations of motion and simulation of structural models of flagella, we demonstrate that dynein does not need to switch direction or inactivate to produce autonomous, propulsive oscillations, but must simply pull steadily above a critical threshold force.
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