ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Focally perfused succinate potentiates brain metabolism in head injury patients.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care.Critical care (London, England) · 2026Review
- Meconium metabolomic profiling dysregulation and neonatal brain injury in selective fetal growth restriction.BMC pregnancy and childbirth · 2026Article
- Amelioration of signaling deficits underlying metabolic shortfall in TREM2The FEBS journal · 2025Article
- Mitochondria: the hidden engines of traumatic brain injury-driven neurodegeneration.Frontiers in cellular neuroscience · 2025Review
- Defining metabolic abnormalities in acute human traumatic brain injury with cerebral microdialysis and multimodality monitoring.PloS one · 2025Article
- Tracing the path of disruption:CNS neuroscience & therapeutics · 2024Review
- Article
- High-physiological and supra-physiological 1,2-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Extracellular Succinate: A Physiological Messenger and a Pathological Trigger.International journal of molecular sciences · 2023Review
- Succinate prodrugs as treatment for acute metabolic crisis during fluoroacetate intoxication in the rat.Molecular and cellular biochemistry · 2023Article
- An overview of clinical cerebral microdialysis in acute brain injury.Frontiers in neurology · 2023Review
- Cerebral microdialysis and glucopenia in traumatic brain injury: A review.Frontiers in neurology · 2023Review
- From Mouth to Muscle: Exploring the Potential Relationship between the Oral Microbiome and Cancer-Related Cachexia.Microorganisms · 2022Review
- Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.Scientific reports · 2022Article
- Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.Brain : a journal of neurology · 2021Observational
- Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation.Scientific reports · 2021Article
- Tumor metabolism and neurocognition in CNS lymphoma.Neuro-oncology · 2021Article
- Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: AMetabolites · 2020Article
- Mitochondrial respiratory chain complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of succinate, a tricarboxylic acid cycle intermediate interacting directly with the mitochondrial electron transport chain, could improve cerebral metabolism. Microdialysis perfused disodium 2,3-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.