Evidence map›Paper›PMID 27798264›Full record

ArticleScience translational medicine2016

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Dongryeol Ryu, Hongbo Zhang, Eduardo R Ropelle, Vincenzo Sorrentino, Davi A G Mázala, Laurent Mouchiroud, Philip L Marshall, Matthew D Campbell, Amir Safi Ali, Gary M Knowels and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 1 synthesis or guideline pooled it, 247 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Redox Molecules in Aging and Neurodegenerative Disorders.International journal of molecular sciences · 2026
    Review
  5. Chemotherapy induces tissue NADbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Cellular Senescence in Skeletal Muscle Aging.Endocrinology and metabolism (Seoul, Korea) · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. NADSkeletal muscle · 2025
    Article
  16. The role of NADnpj metabolic health and disease · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Protein Acetylation and NAD+ Homeostasis in Aging Muscle.Advances in experimental medicine and biology · 2025
    Review

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 3 countries.

Dongryeol RyuLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Hongbo ZhangLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Eduardo R RopelleLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Vincenzo SorrentinoLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Davi A G MázalaDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.
Laurent MouchiroudLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Philip L MarshallInterdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute and Centre for Neuromuscular Disease, Ottawa, Ontario K1H 8M5, Canada.
Matthew D CampbellDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.
Amir Safi AliDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.
Gary M KnowelsDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.
Stéphanie BelleminCentre de Génétique et de Physiologie Moléculaires et Cellulaires, Université Claude Bernard Lyon 1, CNRS UMR 5534, 69622 Villeurbanne, France.
Shama R IyerDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Xu WangLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Karim GarianiLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Anthony A SauveDepartment of Pharmacology, Weill Cornell Medical School, New York, NY 10065, USA.
Carles CantóNestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
Kevin E ConleyDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.
Ludivine WalterCentre de Génétique et de Physiologie Moléculaires et Cellulaires, Université Claude Bernard Lyon 1, CNRS UMR 5534, 69622 Villeurbanne, France.
Richard M LoveringDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Eva R ChinDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.
Bernard J JasminDepartment of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
David J MarcinekDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.
Keir J MenziesLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. admin.auwerx@epfl.ch kmenzies@uottawa.ca.
Johan AuwerxLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. admin.auwerx@epfl.ch kmenzies@uottawa.ca.
École Polytechnique Fédérale de Lausanne · CHUniversity of Washington · USUniversity of Maryland, Baltimore · USUniversity of Maryland, College Park · USNestlé (Switzerland) · CHUniversity of Ottawa · CA

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Translational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5M
NIAMS NIH HHS T32 AR007592NIA NIH HHS R01 AG043930
6 · The paper itself

Abstract

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and nicotinamide adenine dinucleotide (NAD

Indexed as

Poly ADP RibosylationAdenosine DiphosphateAnimalsCaenorhabditis elegansCell LineCytokinesFibrosisGene Expression ProfilingInflammationMaleMiceMice, Inbred C57BLMice, TransgenicMuscle, SkeletalMuscular DiseasesMuscular DystrophiesAdenosine DiphosphateCytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseNitrosaminesN-nitroso-N-methyltyramineRNA, MessengerTyramine

Identifiers

PMID27798264
PMCPMC5535761
OpenAlexW2537034621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.