Evidence map›Paper›PMID 27798225›Full record

ArticleSchizophrenia bulletin2017

The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic Symptoms.

Jean Addington, Lu Liu, Diana O Perkins, Ricardo E Carrion, Richard S E Keefe, Scott W Woods

Open access · bronzeAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Jean AddingtonHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, AB, Canada; jmadding@ucalgary.ca.
Lu LiuHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC.
Ricardo E CarrionDepartment of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY.
Richard S E KeefeDepartment of Psychiatry, Duke University, Durham, NC.
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT.
University of Calgary · CADuke University · USUniversity of North Carolina at Chapel Hill · USYale University · USZucker Hillside Hospital · US

Funding

5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
Enhancing the Prospective Prediction of PsychosisU01MH066069 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2003 to 2007
$1.5M
NIMH NIH HHS U01 MH066069NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

In the literature, there have been several attempts to develop prediction models for youth who are at clinical high risk (CHR) of developing psychosis. Although there are no specific clinical or demographic variables that seem to consistently predict the later transition to psychosis in those CHR youth, in addition to attenuated psychotic symptoms, the most commonly occuring predictors tend to be poor social functioning and certain cognitive tasks. Unfortunately, there has been little attempt to replicate alogorithms. A recently published article by Cornblatt et al suggested that, for individuals with attentuated psychotic symptoms (APS), disorganized communication, suspiciousness, verbal memory, and a decline in social functioning were the best predictors of later transition to psychosis (the RAP model). The purpose of this article was to first test the prediction model of Cornblatt et al with a new sample of individuals with APS from the PREDICT study. The RAP model was not the best fit for the PREDICT data. However, using other variables from PREDICT, it was demonstrated that unusual thought content, disorganized communication, baseline social functioning, verbal fluency, and memory, processing speed and age were predictors of later transition to psychosis in the PREDICT sample. Although the predictors were different in these 2 models, both supported that disorganized communication, poor social functioning, and verbal memory, were good candidates as predictors for later conversion to psychosis.

Indexed as

Disease ProgressionInterpersonal RelationsProdromal SymptomsSocial BehaviorAdolescentAdultChildCognitive DysfunctionFemaleHumansMaleModels, StatisticalPrognosisPsychotic DisordersRiskSchizophreniaclinical high riskpredictionprodromalschizophrenia

Identifiers

PMID27798225
PMCPMC5216866
OpenAlexW2543338994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.