Evidence map›Paper›PMID 27798188›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.

Wei Yu, Randika Parakramaweera, Shavonne Teng, Manasa Gowda, Yashsavi Sharad, Smita Thakker-Varia, Janet Alder, Federico Sesti

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Antagonistic roles of Ras-MAPK and Akt signaling in integrin-KFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Voltage-Gated Potassium Channels as Regulators of Cell Death.Frontiers in cell and developmental biology · 2020
    Review
  19. Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticityFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wei YuDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Randika ParakramaweeraDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Shavonne TengDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Manasa GowdaDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.ORCID 0000-0003-2355-4578
Yashsavi SharadDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Smita Thakker-VariaDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Janet AlderDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Federico SestiDepartment of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 federico.sesti@rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

Oxidation of K+ channels mediates an amyloidogenic pathway common to Alzheimer's disease and TBIR01AG060919 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SESTI, FEDERICO · 2019 to 2023
$2.0M
Oxidative modification of K+ channels as a mechanism of toxicity in TBIR21NS096619 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI SESTI, FEDERICO · 2016 to 2017
$432k
NIA NIH HHS R01 AG060919NINDS NIH HHS R21 NS096619
6 · The paper itself

Abstract

The delayed rectifier potassium (K SIGNIFICANCE STATEMENT: This study provides the first experimental evidence that oxidation of a K

Indexed as

AnimalsApoptosisBrain Injuries, TraumaticCognition DisordersDasatinibHippocampusMaleMiceMice, TransgenicNeurodegenerative DiseasesNeuronsOxidation-ReductionOxidative StressProtein Kinase InhibitorsReactive Oxygen SpeciesShab Potassium ChannelsDasatinibKcnb1 protein, mouseProtein Kinase InhibitorsReactive Oxygen SpeciesShab Potassium ChannelsagingdasatinibKv2.1oxidative stressROSSrc kinases

Identifiers

PMID27798188
PMCPMC5098843
OpenAlexW2545707878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.