Evidence map›Paper›PMID 27798183›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

α2δ2 Controls the Function and Trans-Synaptic Coupling of Cav1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing.

Barbara Fell, Stephanie Eckrich, Kerstin Blum, Tobias Eckrich, Dietmar Hecker, Gerald J Obermair, Stefan Münkner, Veit Flockerzi, Bernhard Schick, Jutta Engel

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 72 citations in OpenAlex.

  1. Transsynaptic linking of calcium channels and postsynaptic receptors at a dyadic synapse.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Presynaptic αNeuron · 2025
    Article
  6. Article
  7. Alpha-neurexins in health and disease.Frontiers in molecular neuroscience · 2025
    Review
  8. Autism-Linked Mutations in αPharmaceuticals (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Presynaptic Nrxn3 is essential for ribbon-synapse assembly in hair cells.bioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. Post-synaptic GABACell reports · 2023
    Article
  13. Article
  14. Article
  15. Pathophysiological Roles of Auxiliary Calcium Channel αHandbook of experimental pharmacology · 2023
    Article
  16. Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022
    Review
  17. αInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Barbara FellDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), and.
Stephanie EckrichDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), and.
Kerstin BlumDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), and.
Tobias EckrichDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), and.
Dietmar HeckerDepartments of Otorhinolaryngology and.
Gerald J ObermairMedical University Innsbruck, Division of Physiology, 6020 Innsbruck, Austria.
Stefan MünknerDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), and.
Veit FlockerziExperimental and Clinical Pharmacology and Toxicology, School of Medicine, Saarland University, 66421 Homburg, Germany, and.
Bernhard SchickDepartments of Otorhinolaryngology and.
Jutta EngelDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), and jutta.engel@uni-saarland.de.
Innsbruck Medical University · ATSaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The auxiliary subunit α SIGNIFICANCE STATEMENT: Inner hair cells possess calcium channels that are essential for transmitting sound information into synaptic transmitter release. Voltage-gated calcium channels can coassemble with auxiliary subunit α

Indexed as

AnimalsCalciumCalcium ChannelsCalcium Channels, L-TypeCalcium SignalingFemaleHair Cells, Auditory, InnerHearingIon Channel GatingMaleMiceMice, Inbred C57BLMice, KnockoutSynapsesSynaptic TransmissionCacna1d protein, mouseCacna2d2 protein, mouseCalciumCalcium ChannelsCalcium Channels, L-TypeAMPA receptorCacna2d2GluA4inner hair cellPSD-95ribbon synapse

Identifiers

PMID27798183
PMCPMC6705655
OpenAlexW2542271086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.