Evidence map›Paper›PMID 27798162›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2016

Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.

Jeffrey J Teoh, Awndre E Gamache, Alyssa L Gillespie, Michael D Stadnisky, Hideo Yagita, Timothy N J Bullock, Michael G Brown

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. NK cell and Th17 responses are differentially induced in murine cytomegalovirus infected renal allografts and vary according to recipient virus dose and strain.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jeffrey J TeohDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908.ORCID 0000-0002-9654-4277
Awndre E GamacheDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908.
Alyssa L GillespieBeirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908.
Michael D StadniskyDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908.
Hideo YagitaDepartment of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; and.
Timothy N J BullockBeirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908.ORCID 0000-0001-6141-3261
Michael G BrownDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908; mgbrown@virginia.edu.ORCID 0000-0003-2872-7685
Carter Center · USJuntendo University · JP

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Regulation of CD8+ T cell responses via liver NK-DC crosstalkU19AI083024 · NIAID · UNIVERSITY OF VIRGINIA · PI ENELOW, RICHARD I · 2009 to 2013
$8.1M
Molecular study of mouse viral resistance mechanisms.R01AI050072 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BROWN, MICHAEL G · 2001 to 2021
$7.1M
NIAID NIH HHS R01 AI050072NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI007496NIAID NIH HHS U19 AI083024
6 · The paper itself

Abstract

NK cells represent a critical first-line of immune defense against a bevy of viral pathogens, and infection can provoke them to mediate supportive and suppressive effects on virus-specific adaptive immunity. In mice expressing MHC class I D

Indexed as

Acute DiseaseAnimalsCD8-Positive T-LymphocytesCell DifferentiationHerpesviridae InfectionsKiller Cells, NaturalMiceMice, KnockoutMuromegalovirusSignal TransductionTumor Necrosis Factor Receptor Superfamily, Member 7Tumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID27798162
PMCPMC5123769
OpenAlexW2540004522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.