Evidence map›Paper›PMID 27798140›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice.

Veronica T Cheli, Diara A Santiago González, Tenzing Namgyal Lama, Vilma Spreuer, Vance Handley, Geoffrey G Murphy, Pablo M Paez

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  5. A computational roadmap to activity-dependent myelination.Frontiers in computational neuroscience · 2026
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  20. Transferrin Receptor Is Necessary for Proper Oligodendrocyte Iron Homeostasis and Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Veronica T CheliHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York University at Buffalo, Buffalo, New York 14203.
Diara A Santiago GonzálezHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York University at Buffalo, Buffalo, New York 14203.
Tenzing Namgyal LamaHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York University at Buffalo, Buffalo, New York 14203.
Vilma SpreuerHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York University at Buffalo, Buffalo, New York 14203.
Vance HandleySemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095, and.
Geoffrey G MurphyMolecular and Behavioral Neuroscience Institute, Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109.
Pablo M PaezHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York University at Buffalo, Buffalo, New York 14203, ppaez@buffalo.edu.ORCID 0000-0001-9362-9454
New York University · USUniversity of California, Los Angeles · USUniversity of Michigan · US

Funding

Modulation of Oligodendrocyte Development by Voltage-Operated Calcium ChannelsR01NS078041 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Pablo Martin Paez · 2013 to 2026
$3.8M
Testing the Calcium Hypothesis of Age-related Cognitive DeclineR01AG052934 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, GEOFFREY G · 2016 to 2020
$2.1M
NIA NIH HHS R01 AG052934NINDS NIH HHS R01 NS078041
6 · The paper itself

Abstract

To determine whether L-type voltage-operated Ca SIGNIFICANCE STATEMENT: Overall, it is clear that cells in the oligodendrocyte lineage exhibit remarkable plasticity with regard to the expression of Ca

Indexed as

AnimalsAnimals, NewbornCalcium Channels, L-TypeCell ProliferationFemaleGene DeletionMaleMiceMice, KnockoutMyelin ProteinsMyelin SheathNeural Stem CellsOligodendrogliaPrimary Cell CultureCACNA1C protein, mouseCalcium Channels, L-TypeMyelin ProteinscalciumCav1.2myelinationoligodendrocytesvoltage-operated Ca2+ channels

Identifiers

PMID27798140
PMCPMC5083013
OpenAlexW2532455505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.