ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
A GABAergic Projection from the Centromedial Nuclei of the Amygdala to Ventromedial Prefrontal Cortex Modulates Reward Behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection.Molecular psychiatry · 2026Article
- Wanting what hurts: D1 dopamine neuronal stimulation in CeA is sufficient to induce maladaptive attraction.Communications biology · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Prefrontal-Limbic Circuitry Is Associated With Reward Sensitivity in Nonhuman Primates.Biological psychiatry · 2024Article
- Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers.Nature communications · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- The Co-Expression Pattern of Calcium-Binding Proteins with γ-Aminobutyric Acid and Glutamate Transporters in the Amygdala of the Guinea Pig: Evidence for Glutamatergic Subpopulations.International journal of molecular sciences · 2023Article
- Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu-opioid receptor.MedComm · 2022Review
- GABAergic and Glutamatergic Phenotypes of Neurons Expressing Calcium-Binding Proteins in the Preoptic Area of the Guinea Pig.International journal of molecular sciences · 2022Article
- Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence.Frontiers in molecular neuroscience · 2022Article
- Article
- Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals.Journal of neuroscience research · 2021Article
- Incentive motivation: 'wanting' roles of central amygdala circuitry.Behavioural brain research · 2021Review
- Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala.eLife · 2021Article
- Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.Science advances · 2021Article
- Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.Science advances · 2021Article
- Suppression of the Swallowing Reflex during Rhythmic Jaw Movements Induced by Repetitive Electrical Stimulation of the Dorsomedial Part of the Central Amygdaloid Nucleus in Rats.Life (Basel, Switzerland) · 2020Article
- Diversity and function of corticopetal and corticofugal GABAergic projection neurons.Nature reviews. Neuroscience · 2020Review
- Optogenetic Activation of the Basolateral Amygdala Promotes Both Appetitive Conditioning and the Instrumental Pursuit of Reward Cues.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Liking and left amygdala activity during food versus nonfood processing are modulated by emotional context.Cognitive, affective & behavioral neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The neural circuitry underlying mammalian reward behaviors involves several distinct nuclei throughout the brain. It is widely accepted that the midbrain dopamine (DA) neurons are critical for the reward-related behaviors. Recent studies have shown that the centromedial nucleus of the amygdala (CeMA) has a distinct role in regulating reward-related behaviors. However, the CeMA and ventromedial PFC (vmPFC) interaction in reward regulation remains poorly understood. Here, we identify and dissect a GABAergic projection that originates in the CeMA and terminates in the vmPFC (VGat-Cre SIGNIFICANCE STATEMENT: Many studies have shown that the interactions between the centromedial nucleus of the amygdala (CeMA) and ventromedial PFC (vmPFC) have critical roles for emotional regulation. However, most studies have associated this circuit with fear and anxiety behaviors and emphasized top-down processing from vmPFC to CeMA. Here, we provide new evidence for bottom-up CeMA to vmPFC influence on reward-related behaviors. Although previous work implicated the CeMA in incentive salience, our results isolate the investigation to a specific CeMA GABAergic projection to the vmPFC. This long-range GABAergic interaction between amygdala and frontal cortex adds a new dimension to the complex regulation of reward-related behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.